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Duloxetine and Clomipramine?

912 views 3 replies 3 participants last post by  Thrombo  
#1 · (Edited by Moderator)
Post Edited by Staff to translate the initial text to English via Google translate:

"Hello. Apparently, I have ADHD and obsessive-compulsive disorder or annoying or intrusive thoughts, but I have to say that I have obsessions and compulsions. I am taking duloxetine 30mg every 2 days because I want to stop it, same with bopropion I was taking a bupropion 150mg but I stopped yesterday, Ritalin 60mg, Bivis which is a high blood pressure medication, Xanax 20mg and Pregabalin 300 MG, and now comes the part that makes me uncomfortable, and I'm thinking whether to continue or not because a week ago my psychiatrist added clomipramine 25 mg. I'm afraid clomipramine together with duloxetine will cause serotonin poisoning or some other complication. Not only that, but I know, he was on too many meds, but bupropion, duloxetine, and Xanax I'm slowly stopping. What is your opinion regarding the combination of clomipramine and duloxetine?"

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Hola. Aparentemente, tengo TDAH y trastorno obsesivo compulsivo o pensamientos molestos o intrusivos, pero debo decir que tengo obsesiones y compulsiones. Estoy tomando duloxetina 30 mg cada 2 días porque quiero dejarlo, lo mismo con el bopropión estaba tomando un bupropión 150 mg, pero lo dejé ayer, Ritalin 60 mg, Bivis, que es un medicamento para la presión arterial alta, Xanax 20 mg y Pregabalina 300 MG, y ahora viene la parte que me hace sentir incómodo, y estoy pensando si continuar o no porque hace una semana mi psiquiatra me agregó clomipramina 25 mg. Me temo que la clomipramina junto con la duloxetina producirá intoxicación por serotonina o alguna otra complicación. No solo eso, sino que lo sé, tomó demasiados medicamentos, pero bupropión, duloxetina y Xanax los estoy deteniendo lentamente. ¿Cuál es su opinión con respecto a la combinación de clomipramina y duloxetina?
 
#2 ·
Duloxetine is a "clean" SNRI and Clomipramine is a "dirty" / unselective SNRI from the TCA class of antidepressants.

I don't think it makes sense to combine those two. The real risk of serotonin syndrome might be relatively low, because the drugs don't increase serotonin by different mechanisms, but it's also an issue that makes me think the combo is not good.