its true....i take parnate 10mg 3 times a day. it is very amphetamine-like....but unfortunately the half life is really short so the effects only last about 1-2 hours. but definetly reminds me of adderral and ritalin...so if u take like 6 pills a day of parnate you could sort of maintain the rush....SSRIs only increase serotonin levels, but MAO is an enzyme responsible for the deamination, or metabolism, of many other neurotransmitters (serotonin, [nor]epinephrine, dopamine, and trace amines such as PEA, DMT, and octopamine).
Tranylcypromine (Parnate) and phenelzine (Nardil) are the two main nonselective MAOIs. Parnate is more energizing, and I've heard it feels kind of like a mild amphetamine. Nardil on the other hand has a metabolite that inhibits the enzyme that breaks down GABA, which makes it the superior anxiolytic/anti-panic agent of the two. Parnate isn't associated with the weight gain Nardil is notorious for, and is also less likely to induce lethargy/daytime somnolence.
Sounds awesome. I just read on Wikipedia that it's an NDRA as well as MAOI (either tranylcypromine itself or a metabolite), so the catecholamine release being potentiated by the MAO inhibition might explain why it has a noticeable psychostimulant effect.its true....i take parnate 10mg 3 times a day. it is very amphetamine-like....but unfortunately the half life is really short so the effects only last about 1-2 hours. but definetly reminds me of adderral and ritalin...so if u take like 6 pills a day of parnate you could sort of maintain the rush....
There's nothing to freak out about, if you follow the special diet you will be fine Also reboxetine could be added to avoid eating a special diet.Parnate sounds awesome.
I've read that one potentially side-effect is death?
MAOI always looked more appealing but the potential side effects freak me out.
Source for that? I know medline used to take parnate with reboxetine, and it was used succesfully for this purpose in a rat studie.I strongly advise against taking NRIs concurrently with nonselective MAOIs. The dose you would need to sufficiently inhibit the NET would be a dose that would cause severe hypertension.
Reboxetine prevents the tranylcypromine-induced
increase in tyramine levels in rat heart
Dostert P, Castelli MG, Cicioni P, Strolin Benedetti M
Farmitalia Carlo Erba,
Research and Development,
Erbamont Group, Milan, Italy.
J Neural Transm Suppl 1994; 41:149-53
This study aimed to examine whether the increase in heart radioactivity levels after intravenous injection of 14C-tyramine to rats pretreated with the irreversible MAO inhibitor tranylcypromine could be antagonized by reboxetine, a potent and selective noradrenaline uptake blocker. Reboxetine was found totally to abolish the effect of tranylcypromine. Heart radioactivity levels after reboxetine and tranylcypromine were very similar to those found when tyramine was injected after reboxetine only. These results suggest that reboxetine might be advantageously combined with tranylcypromine, or any MAO inhibitor, in depressed patients unresponsive of either treatment given alone.