lol same here... ive learned the hard way wiht everythingI have to go offline now, sorry. But please read more about powerful drugs before starting self-experiments. Don't get this wrong... I was like you some years ago, but I learn't the hard way that being well informed means everything when playing psychiatrist.
I skimmed Wikipedia since I wasn't aware of any dangerous or toxic effects from L-Dopa use, and this was located in the article:I've read the script that came with Sinemet throughoutly. The only side effects that worry me are gastrointestinal hemorrhage, blood in urine, hallucinations, hair loss, and dark sweat/urine.
Drug interactions: MOAI, Tricyclic antidepressants, antihypertensive agents, and various dopamie D2 antagonists. They don't mention SSRI or NDRI anywhere.
As for long-term side effects, I could only find one which is "Dopamine dysregulation syndrome" characterized by self-control problems such as addiction to medication, gambling, or hypersexuality.
Did I miss something?
Some studies suggest a cytotoxic role in the promotion and occurrence of adverse effects associated with levodopa treatment. Though the drug is generally safe in humans, some researchers have reported an increase in cytotoxicity markers in rat pheochromocytoma PC12 cell lines treated with levodopa. Other authors have attributed the observed toxic effects of levodopa in neural dopamine cell lines to enhanced formation of quinones through increased auto-oxidation and subsequent cell death in mesencephalic cell cultures.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1476697More serious are the effects of chronic levodopa administration, which include:
- End-of-dose deterioration of function
- On/off oscillations
- Freezing during movement
- Dose failure (drug resistance)
- Dyskinesia at peak dose.
- Recent studies have demonstrated that use of L-dopa without simultaneously giving proper levels of serotonin percursors depletes serotonin.
- The long term use of L-Dopa in Parkinson's disease has been linked to the so called dopamine dysregulation syndrome.
It is unclear if the dopaminergic dysfunction underlying social phobia and Parkinson's disease is to be understood as a biological link between both conditions. Too little is known about the neurobiology of social phobia, and evidence for a common dysfunction remains equivocal. However, in a sample of individuals with social phobia, Tiihonen et al. (1997) identified a dopaminergic dysfunction in the striatum, which also has been found to have the lowest levels of dopamine in Parkinson's disease. Some researchers have suggested that the dopamine deficiency in Parkinson's disease could lead to changes in the noradrenergic system, which in turn are associated with the development of anxiety disorders (e.g., Richard, Schiffer, & Kurlan, 1996). Further evidence that dopaminergic dysfunction may be the biological link between these conditions comes from pharmacological studies suggesting that monoaminooxidase inhibitors (MAOIs) are among the most effective drugs in social phobia, while tricyclic antidepressants have not been found effective for this condition (for a review see Blanco, Schneier & Liebowitz, 2001).
Dopamine agonists would take 2+ weeks to work (probably), unless you used really high doses. Pramipexole would work I suppose, but you'll want to be taking cholinergic supplements to prevent cognitive impairment and psychosis.Thank you but I'm not taking antipsychotics again. I can combine kava with bupropion and fluoxetine, but what about a dopamine agonist? would it be a good idea if I got a dopamine agonist?