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I'm really pissed off right now.

I have been on so many medications over the past 4 years and not a single one has done anything POSITIVE for me. Everyone I have tried has come with unbearable side effects that make me feel so fcking terrible that I want to gouge my eyes out.

I have tried every SSRI, SNRI, Parnate, Emsam, Adderall, Dexedrine.
This is of course for severe depression and social anxiety. I have avoided my anxiety problems for the last 4 months because of my depression.

I was just prescribed Abilify 5 days ago. I feel like complete SH1t right now. Every time I try a new medication I am hopeful. Then a few days pass and I cant wait to get off of it.

I am sick of these medications doctors just throw in my face. I wish I could do this all naturally. I am sorry for the rant.. just feel like **** and don't know what to do. I am trying to get through these first 2 weeks of side effects but this **** is unbearable.

I am more comfortable being "depressed" than on these fcking meds.
Have any of you guys been able to get over depression without medication? I just want to be done with putting this **** into my body.
 

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Severe depression rarely goes away by itself if left untreated, more likely it gets worse and can result in suicide. ECT might be an option, but I don't know much about longterm results. You can use Benzos to ease the side effects the meds give you the first 2-3 weeks. Don't be too hopeful for Abilify, it's complete off-label use, it's not indicated for SA or depression but can have severe (longterm) side effects. In treatment resistant cases combinations of MAOIs like Parnate with noradrenergic TCAs like Nortriptyline can work good. Actually this makes the therapy safer as the risk of a tyramine-induced hypertensive episode is reduced. Klonopin can be added as needed or daily for anxiety. Older Pdocs are more likely to do such combos because they know they are safe.
 

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Adderall, Dexedrine
Wow, literal happy pills don't even make you happy. That's quite an extreme case of depression. This will make you the very first person I've ever come across on SAS who has taken amphetamines for depression. Certainly others take them, but for ADD.

If that still didn't work, I wonder if you could manage to get Desoxyn (methamphetamine), going all the way to the ultimate amphetamine.
 

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I wouldn't recommend that due to neurotoxicity no matter how bad the depression is..
Is methamphetamine any worse in terms of neurotoxicity than dextroamphetamine or amphetamine?

And given that depression can be fatal -- especially for those so severe the Dexedrine or Adderall doesn't even put them in a good mood -- I'm not sure one should worry about the risk of drugs at that point. ECT with its memory loss, decades of misery, or death -- none of the other options look all that appealing you must admit.
 

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I would suggest that you try low dose Buprenorphine for your treatment resistant depression. You won't get a opiate high from that, but for some people it's an instant cure after years of suffering without buildung up tolerance. The κ-opioid receptor antagonism seems to play an important role.
 

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It's expensive but if you can afford it, I would strongly suggest that you visit a Naturopathic Doctor. They will actually take a good hour (or more) to talk to you, do blood and hormone tests that your Medical Doctor would never even think of doing. Based on your results, they will be able tell you what you're ingesting that is toxic for YOU, and customize a diet/supplement/lifestyle plan that would be best for YOU.

In my experience, MDs just throw pills at the problem without bothering to uncover the root cause. If the root cause is not being addressed, then the problem with never fully go away - no matter how chemicals you dump over it. NDs find the root of the problem, and take steps to address it naturally. What a concept huh?!

I have a friend who suffered from really horrible, itchy, dry skin for YEARS. After being prescribed every pill and creme under the sun and nothing working she finally saw an ND and guess what the problem was? Tomatoes. I'm not kidding.

Okay sorry I'm rambling but it just drives me crazy how the researchers, health care system, insurance companies, and society in general favours drugs as opposed to nature. It's all about money - not our best interests, and the sooner everyone realizes this, the better off we'll all be. (IN MY OPINION).
 

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I'm really pissed off right now.

This is of course for severe depression and social anxiety. I have avoided my anxiety problems for the last 4 months because of my depression.

I am more comfortable being "depressed" than on these fcking meds.
Have any of you guys been able to get over depression without medication?
Can you at least move physically? I ask because I read and have seen some people that can barely even move because of their severe depression. What worked for me was zoloft at 50mg, diet and exercise. I have MDD but dont know if its severe enough I just want to sleep most of the time. Nutrition and physical exercise has worked wonders for me like jogging or weight lifting to cope but not cure my mood. I dont think any drug will get to the underlying problem unless you try some sort of therapy.
 

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Supplementing with antioxidants currently isn't a reliable way to prevent methamphetamine-induced neurotoxicity. There have been no studies done on humans regarding this subject, only rats, and the doses they've used thus far to prevent damage in rats have been ridiculous. One study I saw was equivalent to 5 grams of ascorbic acid injected IV into a human.
I've already edited that post. I don't think Methamphetamine is a (good) treatment for depression anyway.
 

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I would suggest that you try low dose Buprenorphine for your treatment resistant depression. You won't get a opiate high from that, but for some people it's an instant cure after years of suffering without buildung up tolerance. The κ-opioid receptor antagonism seems to play an important role.
And what are the odds of getting any doctor to prescribe that for depression?

Some teen/young adult moron in the Milwaukee area died recently from Suboxone, helping give it an even worse image. It got a fair amount of news coverage as she was blond, and really hot (the media seems to love hot blond girls). She was using it recreationally and I guess the source was some junkie on it to treat their drug addiction.
 

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As he already got Adderall and Dexedrine he can also get low dose Buprenorphine. For depression very low doses like 0.2-0.4mg t.i.d. are necessary. Recreationally used the dose is between 4-32mg.
 

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Okay sorry I'm rambling but it just drives me crazy how the researchers, health care system, insurance companies, and society in general favours drugs as opposed to nature. It's all about money - not our best interests, and the sooner everyone realizes this, the better off we'll all be. (IN MY OPINION).
I agree; a lot of mood disorders can be traced back to diet problems, nutrient/vitamin deficiencies, and so on can be cured with nutritional intervention.

However, pharmaceuticals do have a place in treatment, and relying on "natural" treatment just for the sake of them being natural is kinda naive. The herbal remedies that work have pharmacologically-active chemicals in them just like the doc's pills do; the only difference is that herbs are generally less researched and proven due to the lack of funding relative to Big Pharma. Plus you'll be eating lots of other stuff than the active ingredients, and many herbal supplements aren't even standardised and tested.

Recreationally used the dose is between 4-32mg.
I think those doses are for those who've used opiates for years and have a massive tolerance -- if you ate an 8mg bupe without tolerance, you would be rather unwell to say the least. I've seen 0.2mg sublingual tabs sold on a site aimed at recreational/self-medicating users.

And what are the odds of getting any doctor to prescribe that for depression?
Another idea could be to start smoking salvia divinorum every day. Due to its k-opioid agonism, it [presumably] down-regulates those receptors over time and gives an antidepressant effect. Loads of people (myself included) report a pleasant afterglow to the experience; shame it's so unpleasant for me.
 

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I've seen 0.2mg sublingual tabs sold on a site aimed at recreational/self-medicating users.
I took without any opioid tolerance 1mg within 2 hours but felt just subtle mood improvement. Anyway: My point is - If someone gets Adderall and Dexedrine for SA and depression prescribed his chances of getting a Temgesic script for very low dose Bupe-therapy are fairly high IMHO.
 

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It's expensive but if you can afford it, I would strongly suggest that you visit a Naturopathic Doctor. They will actually take a good hour (or more) to talk to you, do blood and hormone tests that your Medical Doctor would never even think of doing. Based on your results, they will be able tell you what you're ingesting that is toxic for YOU, and customize a diet/supplement/lifestyle plan that would be best for YOU.
I agree, although I dont think the member needs to specifically see a naturopathic specialist but some psychiatrists will not even check your urine for any drug screening. I have one clinic in my area that does all lab work but charges a fortune like: Metabolic panels, Free T4's, TSH, CBC, Urinalysis, and ANA for any underlying conditions. Unlike my other psychiatrist who is old fashioned just does pharmacological treatment and psychodynamic treatment which is important but so are other factors.
 

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I'm really sorry to hear that nothing works for you. Paxil sorted my depression out quickly, I guess I'm lucky. But everyone's body is different. I hope you find something that helps. Best of luck.
 

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I agree; a lot of mood disorders can be traced back to diet problems, nutrient/vitamin deficiencies, and so on can be cured with nutritional intervention.

However, pharmaceuticals do have a place in treatment, and relying on "natural" treatment just for the sake of them being natural is kinda naive. The herbal remedies that work have pharmacologically-active chemicals in them just like the doc's pills do; the only difference is that herbs are generally less researched and proven due to the lack of funding relative to Big Pharma. Plus you'll be eating lots of other stuff than the active ingredients, and many herbal supplements aren't even standardised and tested.

I think those doses are for those who've used opiates for years and have a massive tolerance -- if you ate an 8mg bupe without tolerance, you would be rather unwell to say the least. I've seen 0.2mg sublingual tabs sold on a site aimed at recreational/self-medicating users.

Another idea could be to start smoking salvia divinorum every day. Due to its k-opioid agonism, it [presumably] down-regulates those receptors over time and gives an antidepressant effect. Loads of people (myself included) report a pleasant afterglow to the experience; shame it's so unpleasant for me.
thats interesting, the salvia thing, id never do it but out of the box is cool
 

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Eh.. I think smoking salvia would be pushing this a bit far. Simple rebound isn't likely to be anywhere near as strong as buprenorphine anyway. Not to mention you'd probably want mu agonism as well.
I dunno, it would all depend on your dose. If you totally smashed your consciousness apart with mega-doses each night, I'm pretty sure you'd get a noticeable rebound soon enough.

Some more links on the subject regarding oxycodone and buprenorphine, respectively:
I think all this opioid advocacy is a bit short-sighted. Buprenorphine would definitely be an excellent antidepressant with less tolerance and dose-escalation problems than other opioids (due to its k-opioid antagonism), but plain old mu agonists like oxy tend to lead into a never-ending spiral of increasing dose to maintain efficacy.

To be honest, those sites that push mu-agonist opioids as the cure-all are as dumb as that site saying GHB should be prescribed as an antidepressant. Effective? Yeah. Practical? Hell no; to maintain efficacy and avoid crashing you'd have to get into the 24/7 cycle, plus GHB has anti-cognition effects.

When drugs like JDTic get developed, I think we will have our answer. There are ways of dodging the regulation of homeostasis, but we are only beginning to discover them.
 

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There are ways of dodging the regulation of homeostasis, but we are only beginning to discover them.
If you alternate/rotate (or make breaks from) your Benzo of choice with a GABAergic drug like Phenobarbital/Primidone/Mebrobamate/Phenprobamate/Carisoprodol... you can already achieve this in a kind of primitive way.
 
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