Yeah, but it has 5-HT2C antagonism which reduces OCD symptoms. It's got anxiolytic action on 5-HT3 as well, and some other receptors.As for Mirtazapine, Honestly I think its effects on Noradrenaline are pretty mild, it's a far more potent serotonin antagonist. Mirtazapine is a potent 5HT2a receptor antagonsit, and in some cases high doses of drugs which cause 5HT2a receptor antagonism have shown to cause a worsening of obsessive-compulsive symptoms.
Yeah good point, and according to Stahl's Essential Pharmacology text book, I was reading that the 5-HT2C, 5-HT2A antagonism also leads to an increase in dopamine? Mirtazapine and Mianserin have some bizarre mechanisms of action.Yeah, but it has 5-HT2C antagonism which reduces OCD symptoms. It's got anxiolytic action on 5-HT3 as well, and some other receptors.
Also, mirtazapine is likely to be a weak 5-HT2A agonist (in addition to being an antagonist), hence the psychedelia.
Yeah I read that somewhere as well.Yeah good point, and according to Stahl's Essential Pharmacology text book, I was reading that the 5-HT2C, 5-HT2A antagonism also leads to an increase in dopamine? Mirtazapine and Mianserin have some bizarre mechanisms of action.
Remeron is a 5-HT2C antagonist. It inhibits this serotonin system, which when activated causes SA, anxiety, and depressive like symptoms. Inhibiting this system boosts NE and DA in the frontal lobe. That's what I gather from what I researched, what people have said about it, how it works, etc. Read the pharmacology section on Wikipedia. That'll give you what you need to know:Sorry for reviving this thread, but I keep going back to Mirtazapine despite being the only drug that doubles my SA. Could shed some light on my neurotransmitter imbalance.
My recent findings:
I took 60mg a couple of weeks ago just because I'm still curious about it. If 30mg doubled my anxiety, then 60mg tripled it! I felt so horrible and extremely anxious. Any stimulus is enough to scare the hell out of me. Like, if my little sister threw something at me I'd feel those weird shock sensations going through my body, and my heart would beat so hard.
I also experienced insect phobia which I don't normally have. Do you think that Mirtazapine somehow depletes dopamine through an unknown mechanism? I mean, dopaminergic drugs provide a certain degree of anxiety-relief for me. Not to mention that Mirtazapine exacerbate restless leg syndrome which is linked to dopamine dysfunction.
By the way, I tried a couple of noradrenergic drugs and they didn't exacerbate my SA as much as mirtazapine did. So, my extreme reaction to mirtazapine is not only due to its noradrenergic action.
I'm going to take 15mg in a few minutes.
That's quite vivid, but I do relate. There's something about Remeron which redirects the mind into the self . . . that's why sleep and dreams become so interesting. The problem is that the mind is then directed toward . . . SUGAR in a frightful way.I find people extremely disgusting. This is one of the weirdest side effects of Remeron. People make me sick to my stomach, and the idea of having sex with someone is now extremely repulsive. This is enough to make me libido-less even if indirectly.
It's pharmacological profile basically adds up to this;Remeron is a 5-HT2C antagonist. It inhibits this serotonin system, which when activated causes SA, anxiety, and depressive like symptoms. Inhibiting this system boosts NE and DA in the frontal lobe. That's what I gather from what I researched, what people have said about it, how it works, etc. Read the pharmacology section on Wikipedia. That'll give you what you need to know:
Mirtazapine is a potent antagonist at the following receptors: H1 (~0.75 nM) > 5-HT2A (~10 nM) = 5-HT2C (~10 nM) = 5-HT3 (~10 nM) > α2-adrenergic (~100 nM).
Basically you got an antihistaminergic, which will make you sleepy. 5-HT2C is supposedly where the clinical benefit is. 5-HT2A antagonism is the opposite of what SSRI do (they upregulate these receptors for clinical benefit). And then 5-HT3 and adrenergic which is where you get your dry mouth, etc. side effects.
That being said, the 5-HT2C antagonism effects of Remeron are VERY good at anxiolysis.It's pharmacological profile basically adds up to this;
α2-adrenergic antagonism ( + indirect α1 stimulation) = antidepressant effect (Serotonin and Norephedrine disinhibition)
5-HT2C antagonism = antidepressant effect (Dopamine and Norephedrine disinhibition)
5-HT2C + 5-HT2A antagonism = anxiolytic effect
5-HT3 antagonism = anti nausea effect
H1 antagonism = drowsiness and increased appetite effect
http://www.cnsforum.com/content/pictures/imagebank/hirespng/Drug_nassa.png
How much do you usually take? I just moved back up to 45 mg again. 30 mg was waning in effect a bit.That being said, the 5-HT2C antagonism effects of Remeron are VERY good at anxiolysis.