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prozac can stunt your physical development and of male sexual charecteristics

8547 Views 20 Replies 13 Participants Last post by  AnnBlakeTracy
hi im an irish guy who was on prozac from 18 to 27 for ocd, only now having been of prozac almost 2 year s have i become aware of how durring that time not only did i not gain in height but also failed to fill out physically, i am 5"8 smaller than my father brother male cousins etc. most of my school mates who were my height at 18 had a late growth spurt something which never happened to me; also i didnt grow any facial hair while on prozac bar some on my neck and chin anyway becoming more aware of my lack of physical development and male characteristics after coming off prozac i googled " prozac stunts growth" and alot of scary studies confirming prozac stunts growth came up dating back to 1998 the year i began prozac despite the fact that no where on an ssri list of side effects will you see this, i also noticed studies pointing out possible problems with testes development in teenagers on ssris. you can imagine how angry i feel about this and please dont think im being superficial my main concern is because at the moment i do physical work and find it very challanging due to the fact that my arms an upper body bone structure is narrower and smaller than colleagues, i know other people who are smallish but they tend to have compensated by being stockier. anyway the reason i am posting this thread is to highlight this danger to anyone on an ssri or considering trying it, however i would also like to hear from anyone who may have experienced stunting of growth, puperty etc. as i would like to start some sort of campaign to highlight what i regard to be a very seroious issue especially given that its estimated that 1 in 6 american teenagers are or have been on an ssri and its increasingly being prescriped to teenagers in europe.
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From what I understand basically the increase in serotonin triggered by an SSRI can interfere with the dopaminergic and noradrenergic systems and as a result cause an elevation of prolactin levels.

Dopamine and norepinephrine normally play a large role in the regulation of testosterone, and cause an increase in testosterone production due to inhibition of prolactin.

Catecholamines stimulate testicular testosterone release of the immature golden hamster via interaction with alpha- and beta-adrenergic receptors.

Several lines of evidence suggest that catecholamines are involved in the regulation of the development of the testis. We have therefore investigated the ability of testicular parenchyma (decapsulated pieces of testes) from 18 to 20-day-old golden hamsters to respond to catecholaminergic stimuli in vitro. Norepinephrine and epinephrine, as well as the beta-receptor agonist isoproterenol and the alpha-adrenoreceptor agonist phenylephrine were able to significantly stimulate testicular testosterone production. Dopamine and serotonin were not effective. The stimulatory action of norepinephrine on testosterone production was dependent on the concentration. In incubations of testes with human chorionic gonadotropin (hCG) and norepinephrine, no synergistic effects on testosterone release were observed. The stimulatory effect of norepinephrine could be partially blocked by incubation with beta-receptor antagonist propranolol, or with alpha-receptor antagonist prazosin, while a combination of propranolol and prazosin completely inhibited the norepinephrine-induced testosterone production. Moreover, isoproterenol and phenylephrine in combination stimulated testosterone more than either drug did alone. Measurements of concentrations of norepinephrine and epinephrine in testicular homogenates revealed higher values for these catecholamines than in the plasma, implying that catecholamine levels in the interstitial spaces of the testis might be in the range of concentrations effectively stimulating testosterone production in vitro. This suggests that in the immature testis of the golden hamster, catecholamines acting through both alpha- and beta-adrenergic receptors may be potent physiological stimulators of testosterone production.
I was fully grown before having taken any anti-depressant. I did take Depakene at ages 4-6 which I believe has permanently ****ed my appetite.
Did it cause a permanent increase or decrease in your appetitte?
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