!! That's quite a huge amount. 1500mg? Are you sure? Haven't you noticed anything in your hands/feet??ive been using 100mg of p5p with 1500mg of b6 for about a month and haven't noticed anything.
Sure, but that is not the case with p5p:I used to take 1-2Neurobion/day (containing 200mg of B6 each, as pyridoxine) for 2-3 months, and started having mild sensory neuropathy for a few days. (Basically my hands and feet had a pins-and-needles, tingling sensation, it was very noticable). I stopped the B6 and it stopped within 2-3 days.
Too much B6 is pretty dangerous...
It is important to take the active co-enzyme form of B6, pyridoxal-5-phosphate (P-5-P.) Many B6 supplements are the inactive pyridoxine HCL form. In some cases, supplementation of the pyridoxine HCL form singularly and in doses as low as 200 mg daily over 3 years caused a reversible numbness & tingling of the extremities. This problem was thought to be secondary to the liver's inability to convert the pyridoxine HCL to the pyridoxal-5-phosphate form (which requires vitamin B2, magnesium & a well functioning liver.) Using P-5-P avoids this problem.*