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Eur Neuropsychopharmacol. 2005 Oct 20;

Red cell membrane omega-3 fatty acids are decreased in nondepressed patients with social anxiety disorder.

Green P, Hermesh H, Monselise A, Marom S, Presburger G, Weizman A.

The "phospholipid hypothesis" attributes a pathophysiologic role to the polyunsaturated fatty acid (PUFA) composition of phospholipids in depression. The aim of the present study was to determine whether the hypothesis is relevant to social anxiety disorder (SAD). The study sample consisted of 27 untreated, nondepressed patients with SAD (DSM-IV) and 22 controls. Severity of SAD was assessed with the Liebowitz Social Anxiety Scale (LSAS). Erythrocyte PUFA concentrations were measured by gas-liquid chromatography. Concentrations of most n-3 PUFAs were lower in the patients: 18:3n-3 by 32% (p<0.002), 20:3n-3 by 34%, 20:5n-3 by 36% (all p<0.001) and 22:6n-3 by 18% (p=0.002). No significant differences were observed in other fatty acids. Significant inverse correlations were obtained between levels of n-3 PUFAs and LSAS scores. In conclusion, the phospholipid hypothesis may apply to SAD, thereby opening new therapeutic options. The robust relationship between low erythrocyte n-3 PUFA concentrations and SAD justifies exploration of relevant neuropathophysiological mechanisms.
 

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Discussion Starter · #7 ·
mobile363 said:
yup, flax seed oil is a better source for Omega 3's. I just take a tablespoon of flax seed oil each day.
The omega-3 oil rich in flax seed is alpha-linolenate. It can be converted in body to the omega-3 oils rich in fish (EPA and DHA).

i.e. alpha-linolenate>>>>EPA>>>>>DHA

Flax seed oil may be a better option because it doesn't have as much lipid peroxidation potential as fish oils (EPA and DHA) as it has fewer double bonds (3 as opoosed to 6). And it tastes better. The only negative is that it is kinda expensive. Walnuts and green vegetables are also a source of this oil. Flax seed oil also needs to be refrigerated. Either way increasing omega-3's is probably good for overall heath.
 
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