Does anyone know if I can combine Nefazodone with Pristiq? Pristiq works for my depression but increased my anxiety. I took Serzone years ago and it worked the best for social phobia. I've been on Nefazondone for a week and trapering off Pristiq but my depression is rearing its ugly head. So... today I'm trying 50mg Pris in the A.M. (helps with energy too) and add 100mg Nef, in the P.M. 100mg Nef. Thanks for your feedback.