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nardil user since 2006
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Discussion Starter #1
so far i haven't/couldn't orgams in 3 weeks more or less. my pdoc said there was nothing as far as meds go that can fix it for MAOI induced anorgasmia. only lowering my dosage of nardil. i tried horny goat weed, my libido increased tremendously, but didn't orgasm, and it only worked once, the first time i tried it. now i get nothing out of it. i heard benadryl can help, but i tried it and all it did was get me sleepy. anything i could try to help me with anorgasmia? thanks.
 

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That sucks...3 weeks OMG! That's why I never want to try SSRI's again because they all do that to me; can't imagine what an MAOI would do to me! As a guy in his twenties that side effect out of the question.
 

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Equilibrian Epicurius
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I didn't get any sexual dysfunction from Nardil until 3-4 weeks into monotherapy, then it suddenly got to a point of 100% anorgasmia for a couple weeks thereafter. I've since quit Nardil altogether, due to a lack of efficacy after almost 9 weeks from commencing treatment.
 

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nardil user since 2006
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Discussion Starter #4
i guessi could try 4grams of horny goat weed, buts thats like 4 times the normal dosage ppl take. 2 grams does jack squat. luckly i haven't felt nauseous at that dosage or anything, yet. need some suggestion folks.
 

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i guessi could try 4grams of horny goat weed, buts thats like 4 times the normal dosage ppl take. 2 grams does jack squat.
Icariin increases production of nitric oxide, it doesn't do anything to increase libido or prevent anorgasmia though. Mirtazapine is supposedly a safe drug to combine with maois to prevent sexual dysfunction.
 

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As for erectile dysfunction medications like sildenafil (Viagra), they will NOT help you as they only improve blood flow and erection, not the actual process of orgasm.
You sure?

Sildenafil in the Treatment of SSRI-Induced Sexual Dysfunction: A Pilot Study.

Damis M, Patel Y, Simpson GM.
Department of Psychiatry, University of Tennessee at Memphis Health Science Center, Memphis; and the Department of Psychiatry and the Behavioral Sciences, LAC/USC Medical Center, Los Angeles, Calif.

BACKGROUND: Sexual dysfunction is a well-documented side effect of selective serotonin reuptake inhibitors (SSRIs). Commonly reported side effects include erectile impotence, anorgasmia, ejaculatory delay, pain, loss of sensation, and decreased pleasure. Early reports of the reversal of sexual dysfunction after using sildenafil in male and female patients receiving various types and dosages of SSRIs are promising and prompted this study. Our aim was to evaluate the effects of oral sildenafil on reported secondary sexual dysfunction in patients concurrently treated with SSRIs. METHOD: Fourteen male patients who developed sexual dysfunction while receiving SSRIs were screened using the Arizona Sexual Experience (ASEX) scale. An electrocardiogram was obtained at the beginning and at the end of the study. Each patient was prescribed sildenafil tablets to be taken twice a week, 25-100 mg, prior to sexual activity and told to record the findings in a running diary which he was to keep during his treatment period. The patients were seen weekly and evaluated by clinical interview and ASEX scale. Patients were treated for a total of 8 weeks. RESULTS: All but 1 of the 14 patients experienced an improvement of sexual dysfunction, with 9 patients at the first dose of 25 mg and 4 at higher doses (3 at 50 mg and 1 at 75 mg). One patient required 100 mg to obtain minimal response. DISCUSSION: Sildenafil was shown to be helpful in the treatment of SSRI-induced sexual dysfunction. Three patients continued to experience ongoing positive effects after discontinuation of sildenafil; the other 10 patients relapsed.
High-dose sildenafil citrate for selective serotonin reuptake inhibitor-associated ejaculatory delay: open clinical trial.

Seidman SN, Pesce VC, Roose SP.
Department of Psychiatry, College of Physicians and Surgeons of Columbia University, and the New York State Psychiatric Institute, New York, NY 10032, USA. [email protected]
BACKGROUND: Selective serotonin reuptake inhibitor (SSRI)-induced ejaculatory delay is a common problem that has no treatment with established efficacy. Sildenafil citrate is effective for erectile dysfunction and appears to be safe at doses up to 200 mg. METHOD: We enrolled men who were in remission from depression according to DSM-IV criteria and who reported that they had developed new-onset ejaculatory delay in the setting of SSRI treatment. Enrolled patients were instructed to use 25 mg of sildenafil 1 hour prior to sexual activity on at least 2 occasions. If this was not effective for the ejaculatory delay, they were instructed to increase the dose progressively up to a maximum of 200 mg. We compared baseline sexual functioning to 2 phases of open treatment: low-dose phase (sildenafil 25-100 mg) and high-dose phase (sildenafil 150-200 mg). The primary outcome measure was a modified, self-report Clinical Global Impressions (CGI) scale that was specific for erectile (CGI-EF) and ejaculatory (CGI-EJF) aspects of sexual function. RESULTS: Twenty-one men (mean age = 56 years) with major depressive disorder (MDD) in remission and SSRI-associated ejaculatory delay enrolled in the study and received sildenafil. At baseline, 14 of 21(67%) had comorbid erectile dysfunction. At the low-dose phase follow-up assessment, 12 of 14 achieved full erectile dysfunction remission, and 4 of 21 achieved ejaculatory delay remission. Sixteen patients with persistent ejaculatory delay were eligible for the high-dose phase: 5 withdrew from the study, 4 increased to a maximum dose of 150 mg, and 6 increased to a maximum dose of 200 mg. The 1 patient who had clinically significant erectile dysfunction and ejaculatory delay reported improvement of both conditions after the high-dose phase. Of the 10 patients who had ejaculatory delay without significant erectile dysfunction and who chose to take high-dose sildenafil, 9 reported a significant clinical improvement in ejaculatory delay (CGI-EJF improvement score of 1 or 2) and 7 achieved full remission (CGI-EJF severity score of 1 or 2 and CGI-EJF improvement score of 1 or 2). CONCLUSION: In this open clinical trial with men who had SSRI-induced ejaculatory delay, high-dose sildenafil appeared to be effective in reducing ejaculatory latency.
An open trial of oral sildenafilin antidepressant-induced sexual dysfunction.

Fava M, Rankin MA, Alpert JE, Nierenberg AA, Worthington JJ.
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Mass. 02114, USA.
BACKGROUND: Sildenafil is a selective inhibitor of cyclic GMP-specific phosphodiesterase type 5 that has been associated with greater improvement of erectile function compared to placebo among men with erectile dysfunction. The goal of our study was to evaluate its efficacy in a small sample of outpatients with antidepressant-induced sexual dysfunction. METHODS: We studied the first 14 depressed outpatients (9 men and 5 women; mean age: 46.4 +/- 8.4) who were consecutively treated with oral sildenafil. Twelve of the 14 patients were treated with an SSRI and 2 with mirtazapine. All patients were prescribed oral sildenafil tablets at the initial dose of 50 mg q.d. p.r.n., with the possibility of increasing the dose to 100 mg q.d. p.r.n., if clinically indicated. We administered a sexual functioning questionnaire derived from the Guided Interview Questionnaire for females and males and from the Arizona Sexual Experience Scale to all patients before and after at least 4 weeks of treatment with oral sildenafil. The mean sildenafil dose in our 14 patients was 57 +/- 18 mg/day. RESULTS: All 14 subjects completed the follow-up assessments and no subjects discontinued the drug prematurely. We observed statistically significant improvements in all domains of sexual functioning, including libido, arousal, orgasm, sexual satisfaction, and (in males only) erectile function, with a 69% rate of patients reporting themselves as much or very much improved. Oral sildenafil treatment appeared to be very well tolerated, with only 1 out of 14 (7%) patients reporting an adverse event (hot flashes). CONCLUSIONS: Our findings of statistically significant improvements in all domains of sexual functioning in a sample of 14 men and women with antidepressant-induced sexual dysfunction suggest that this agent may represent an efficacious approach to this population.
 

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yea try buspar!! thats worked for me alot. On effexor I couldnt get an erection or have an orgasm and i took buspar and basically went back to normal. Though serotonin syndrome is possible, but rare. wellbutrin could work but anxiety is a side effect.
 

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nardil user since 2006
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339 Posts
Discussion Starter #8
thanks for the info guys, i could get the supplement online, as for the meds, i could ask my pdoc about em. i can't afford brand name though, so viagra even if it does work, its still under patent, and i can't afford.
 

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nardil user since 2006
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339 Posts
Discussion Starter #10
well i took 4 grams of horny goat weed prior, which i felt nothing. i just took 15mg of buspar. now im waiting.. will buspar diminish the effects of nardil?
 

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nardil user since 2006
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339 Posts
Discussion Starter #11
You sure viagra is under patent? Here in the UK it's available as a generic without a pescription.
well...i could get generic viagra online but its still pretty darn expensive. 100mg 32 tablets at $125 USD.
 

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nardil user since 2006
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339 Posts
Discussion Starter #13
how much buspar does it take you? and how long after taking buspar do you feel the effect?
 

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nardil user since 2006
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339 Posts
Discussion Starter #14
whew.... well i finally orgasmed late last night. i hope to think it was the 15mg buspar i was taking. i actually felt my prostrate shrinking in size; yeah i was worried about it.
 

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.....

I WANNA ORGASM TOO!

BOOOO!!

WAAAAAH!

* whines like a little kid *

* sigh *

Oh well. By the way, fabulous work ;)
YOUR NOT TRYIN HARD ENUF BOY. U GOTTA GIVE IT UR ALL. just playin
Hey im really happy the buspar is/might be working. It really works for that kind of stuff for me. good luck
 

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In the doghouse
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Buspar never worked for me in this regard. Although, it seems to work for other people so I hope it works for you. I take Effexor and the ability to shoot my load returned with time. I have no clue what "horny goat weed" is and i'm not looking it up. :- ) However just plain old "weed" helped me out quite a bit if you don't mind the other effects.

Maybe you need new material. Which is certainly widely available!
 

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Horny goat weed is such a stupid name for an aphrodisiac.

1. It makes me think about aroused mountain goats.
2. Impotence is a better option than taking something labelled "horny goat weed" to the checkouts in a supplement shop.
 

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maoi's side-effects tend to decrease over time in contrast to ssri's which do not.
if you have the patient you're a lucky guy (if nardil works for you of course).
 
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