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Discussion Starter · #1 ·
So it seems to be that latly there is becoming a trend of doctors mixing and matching certain medications for enhanced benefits.

So I'm curious if anybody has tried out any successful combinations, like for example;

Lexapro+Wellbutrin+Lyrica or

Effexor+Mirtazapine (ie california rocket fuel)
 

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a placebo blind trial would be needed for the placebo effect, I suspect many of these 'off label' cocktails are promoted by the drug cos that sell them
 

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Discussion Starter · #3 ·
There have been studies done already regarding the combination of mirtazapine and venlafaxine (effexor), with evidence suggesting that it is more effective than mirtazapine augmentation of SSRI's, and has a faster onset of action and shorter time to recovery than mirtazapine augmentation of fluoxetine. http://www.ijpm.org/content/pdf/327/casemg.pdf

Not sure about any other combinations though, with regards to clinical evidence vs anecdotal evidence.
 

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There have been studies done already regarding the combination of mirtazapine and venlafaxine (effexor), with evidence suggesting that it is more effective than mirtazapine augmentation of SSRI's, and has a faster onset of action and shorter time to recovery than mirtazapine augmentation of fluoxetine. http://www.ijpm.org/content/pdf/327/casemg.pdf

Not sure about any other combinations though, with regards to clinical evidence vs anecdotal evidence.
Fluoxetine has the longest half-life of all the SSRIs (and longest time to peak concentrations), so that evidence is very very very biased. Of course it's gonna take longer to recovery when you have to build up the fluoxetine levels gradually.
 
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