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There is apparently only one report that the butanedisulfonate SAMe is superior to the tosylate SAMe and reviews from using the products seem to say that they get as much benefit from the less expensive as the more expensive.

Any views on this or is there anyone in the know out there?
 

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I'm sure you can do a quick google search to find out if either ligand has a great effect on bioavailability. That would be the main concern, is how well each is actually assimilated by the body. I personally have no idea and am not inclined to search the web for you but I'm sure that you can find a conclusive scientific answer within 5 minutes. Personally, regardless of the Ligand I don't think SAMe does anything so I wouldn't waste the money even on the cheaper formulation.
 

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I used to take Sam e and it didn't seem to do anything but make me feel hyper for the first few times but even that affect wore off and it ended up doing nothing for me.


The best things you can do for mental health is diet + sleep hygiene + exercise + increased social contact.
 
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