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ever since i have gone up to 187.5mg effexor i now have intensified my PRE-EXISTING anhedonia. I need to stay on this cuz i get significant anxiolytic relief BUT considering these ssris/snris cause permanent gene alterations is my anhedonia going to be permanet? is it possible to actually feel real pleasure once again or are our dopamine systems ****ed forever?
 

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No, I wouldnt expect it to be permanent at all. But it sounds like you need to augment your regimen to get rid of the effexor induced anhedonia. Anhedonia on its own can be helped by a variety of meds but effexor probably has a **** ton of interactions so you need to use caution.
 
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