After 14 days of PPX treatment, the firing rate of DA had recovered as well as that of NE, whereas the firing rate of 5-HT neurons was increased by 38%. It was also observed that sustained PPX administration produced desensitization of D(2)/D(3) and 5-HT(1A) cell body autoreceptors, as well as a decrease in sensitivity of alpha(2)-adrenergic cell body autoreceptors. These adaptive changes are implicated in long-term firing rate adaptations of DA, NE and 5-HT neurons after prolonged PPX administration. In conclusion, the therapeutic action of PPX in depression might be attributed to increased DA and 5-HT neurotransmission.
sorry lol...i wasnt trying to bash the dopamine agonists. they are very cool, and acutally Requip helps me also when i take it. i just meant that it wouldn't really cause effects that one would expect to get from agonizing DA receptors.... well, most antipsychotics are D2/3 antagonists, ....its really funny, cuz most of the psychotics also cause an acute release in dopamine. like amisulpride, for example...its antidepressant at low antagonism of D2.....but its all good. Requip and Pramipex should be used alot more with SSRIs and stuff.I disagree, because activation of D2 and D3 by this meds have effect. For me it's antidepressant, and anti anhedonic effect. I'm not tolerate any SSRI and wellbutrin, mianserin make me feel like a zombie. Only ropinirole works, so please don't generalize, because it's not popular med.
If "telling the neurons to release less dopamine" so why this meds it's not prescribed for schizo? And one of the side effect is gaming and hypersexuality?
And why it's one of the best med for parkinsons?