I was recently put on Depakote 500mg BID along with Lopressor 25mg QD. I used to take Effexor XR, Neurontin, and Xanax daily, but I was taken off all of them by a different psychiatrist. Anyway, I was wondering if anyone had any experience with Depakote. I know that it is not used for treating anxiety, but I've read that Depakote acts as a GABA transaminase inhibitor to some extent (i.e. it inhibits GABA from breaking down) and I think I might be experiencing some of the expected anxiolytic effects from it. Is this effect very pronounced - is it actually noticeable as I have described? Or is it more like Neurontin's don't-know-it's-there-til-it's-gone type of action? I think I felt it more when I first began treatment with it a few weeks ago. I haven't had a valproate trough yet to see what my valproate level is, but I feel like I could withstand an increase in dosage to 500mg TID if it means getting that initial feeling back :yes Thanks in advance for any responses!