Actually I would prefer the combination of both. Releasing dopamine and at the same time inhibiting it's reuptake sounds interesting. Could be a little bit dangerous too... who knowsThe only legal drugs that could enhance dopaminergic transmission in my country are Bupropion (Wellbutrin XL), and Sulpiride (Dogmatil). The pharmacist said that he will search the database for Amisulpride meanwhile.
Bupropion is a dopamine and noradrenaline reuptake inhibitor.
Sulpiride/Amisulpride are antipsychotic drugs that can enhance dopaminergic transmission at very low dose.
Which would you prefer for dopamine and why?
(Be noted that I will most likely add an SSRI)
150mg Sulpiride were given in the studies I saw for depression.I know that 50-200mg is a low enough dose of Amisulpride, but what about Sulpiride?
Don't crush the Wellbutrin (XL) tablets! If you want to do this experiment, then start with the lowest dose (150mg) as a whole tablet.And, shouldn't I take a dose lower than 150mg of bupropion (XR) if I take it with one of the above? The wellbutrin that is available is the extended release version, so I shouldn't really crush it, etc.
Maybe even better regardless of side effects? Sounds like there's a lot of dopaminergic action going on here. I may want to try this combo if it's significantly more stimulative than bupropion by itself.If you added an SSRI to this regimen of yours, I'll bet your response would be either on par with or superior to that of an MAOI. Lower side effects, no food restrictions, and no drug interactions either.
What time do you take the fluoxetine? Night is best in my opinion.I've added Fluoxetine to my regimen.
My current regimen/day:
Bupropion (SR) 150mg
I'll keep you informed of improvements. If I didn't notice an improvement within 2 months I'll raise the Fluoxetine to 40mg/day. If that didn't work I'll start crushing the wellbutrin pills or take them sublingually. If that didn't work as well, I will stop with this regimen and get back to my Xanax or figure out something new...
So I'm giving the whole thing 4 months from now. Which, in my opinion, quite sufficient for testing it. (Unless some extreme side effect came up, i.e. mania)
Why did you stop the selegiline and Lexapro?I kicked away my Lexapro cold turkey without having any WD symptoms and stopped the Selegiline too. I already have a script for Wellbutrin 300mg and will likely get Solian (Amisulpride 50mg x 50) in 4 days (it's very easy to get in my country). When I have that stuff I'll mix it with Klonopin 2mg bid and see what happens. I think Amisulpride is better than Sulpiride for things like that.
I think I don't need these drugs anymore.But Medline I thought your regimen worked very well for SA. What happened?
I guess I won't use this combo. I have another reason too. I had alcohol problems in the past and 50mg Amisulpride seem to make alcoholics drink even more: http://cat.inist.fr/?aModele=afficheN&cpsidt=14002091By the way, let me know if one of your eyelids start twitching after welbutrin+amisulpride. My right eyelid has been twitching for two days even on xanax. It kinda gets annoying after a while.
I'll think about it, but I'm not convinced.Selegiline would boost Wellbutrin so you don't get as much noradrenaline with lower doses, and Lexapro would relieve any anxiety...
You started on 20mg fluoxetine? That's bound to be a horrible experience. I recommend starting at 5mg or less and titrating up slowly in 1-5mg increments. Also, mirtazapine or trazodone could fine-tune its effects.Since I added Fluoxetine to the mix 5 days ago and I noticed these effects:
- I'm no longer smiling for no reason.
- I'm no longer stimulated. (Have to drink tea now)
- I'm very tired yet I can't fall asleep / easily interrupted sleep. (Insomnia)
- My dreams got more bizarre and less enjoyable.
- Diarrhea, vertigo, excessive sweating and urination.
- Easy muscle spasms / overall fatigue.
- Random twitching.
- Loss of appetite.
- Increased libido.
- Auditory distortion is still there. Music being transposed up or down briefly.
The most intense are diarrhea and insomnia.