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Discussion Starter · #1 ·
Just curious, you know, mix 2 pounds of Altoids, 4 bottles of pepto dismol, one Twix bar, you know where I'm getting it lol jk.

Seriously though, just curious or is it all prescription based?
 

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There exist the OTC antihistamines like diphenhydramine that pass the blood brain barrier - they may calm somebody down, I consider them dumb drugs. DXM is available too, but I don't think it's a brilliant idea to use it as a tool to self-treat SA. Other options are stuff like Valerian, L-Theanine, L-Glutamine, St. John's Wort and stuff that can be bought online without prescription like Picamilon, Phenibut... The most potent OTC anxiolytic is readily available: Alcohol... If one thinks he lives in hell because of SA & depression... self-treat with alcohol long + hard enough and then you know what real hell is.
 

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^^are you saying its impossible to self medicate with alcohol for years without encountering problems??id have to disagree, i know quite a few people that drink as soon as they get home from work...a few beers nothing more..they have done this for YEARS and dont seem to suffer from it..now, i know many will encounter problems down the road from this but some can do it..

dipenhydramine will lessen anxiety but it just makes me feel numb, very disinterested in everything..
 

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^^are you saying its impossible to self medicate with alcohol for years without encountering problems??id have to disagree, i know quite a few people that drink as soon as they get home from work...a few beers nothing more..they have done this for YEARS and dont seem to suffer from it..now, i know many will encounter problems down the road from this but some can do it..
My point is: Self-treating psychiatric problems like a severe anxiety disorder or depression with alcohol is a bad idea. ;) Btw: "A few beers" daily is already too much - longterm (inreased risk for liver / pancreatic / cardiovascular... disease, cancer...).
 

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Yes, alcohol is definitely the easiest and most effective over the counter treatment if you are willing to endure the side effects and the disadvantages it will have on you health and longevity. Drink responsibly.
 

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Just curious, you know, mix 2 pounds of Altoids, 4 bottles of pepto dismol, one Twix bar, you know where I'm getting it lol jk.

Seriously though, just curious or is it all prescription based?
I don't think you would get any serious relief with over the counter stuff. Sedatives like Benadryl, Melatonin, etc. could help you out. I always found melatonin made me feel happy, but it also put me out.

St. John's Wort is an alright herbal remedy, although not real strong.
 

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Ditto what medline said.

For severe chronic anxiety there aren't any good OTC possibilities. The antihistamines work a little (unless you take too much and then you have a paradoxical reaction) bit but they make you drowsy so they are mainly for insomnia. Valerian is the best balance between safety and efficacy that I've found for anxiety, but it is probably not enough for severe anxiety. I have a lot of body anxiety so I will take valerian every once in a while, but again it makes me a little too sleepy.
 

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Discussion Starter · #8 ·
I just.. cant converse man.. Its hard talking to people I know..and I dont really feel anxiety around people I work with, just people I've never seen before or like this one girl at work that I kinda gotta thing for, I get nervous whenever around her.
 

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Yes... it often seems like society WANTS to drive people to alcoholism when the only other way to get relief is to grovel to a power-tripping doctor who may or may not give you something good.
 

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Yes... it often seems like society WANTS to drive people to alcoholism when the only other way to get relief is to grovel to a power-tripping doctor who may or may not give you something good.
I read this message a couple days ago and didn't think much of it, but now that I really think about it. I agree with you. In our society it is easier to drink and do illegal drug than it is to get real help. Most people who are alcoholics or drug addicts probably would rather have real help.
 

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The best thing to do is to get to a doctor.
Other than that, there is Valerian root, Kava Kava, and a product I have been trying with some success - Rescue Remedy and Rescue Sleep Sprays. You spray it twice on the tongue and the herbs do their work. The only problem is that the herbs are suspended in 27% alcohol, but the sprays are small and not habit-forming. It's like a weak NyQuil. They actually work.

I am already on Paxil, so these products are safe. I bought them at the health food store.
 

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rocknroll714, where do they sell L-dopa and nitrous over the counter? Haha. Oh and with DXM, are you referring to Olney's Lesions?
 

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L-DOPA is in Mucuna Pruriens which you might be able to get OTC and N2O is in whippets of course! I've gotten N2O OTC in the form of whippets before. And DXM yeah, Olney's lesions, not to mention all the user reports of severe retardation after taking it.
Olney's lesions have never been observed in humans. And the doses rats have been given in studies are very, very high.

And in rats, it's an effect from pretty much all dissociatives (to be more precise, NMDA antagonists). Yes, that INCLUDES nitrous oxide, which administered to rats has been specifically observed to produce vacuolization... it's every bit as bad if you're concerned about Olney's lesions. Which you probably shouldn't be anyway, because as pointed out, the doses required are beyond extreme, and it hasn't been seen in a single human. In reasonable doses DXM, like other NMDA antagonists, is actually considered to be fairly neuroPROTECTIVE.

That being said, I still don't use DXM for anything other than cough suppression (which is rare, because my GP will prescribe me hydrocodone syrup for a cough!)

I know ketamine in particular has been studied as an antidepressant and from what I've read, it can have very powerful and rapid effects - although relapse is almost certain without some kind of continued therapy. Although, up until a few years ago I used to use ketamine semi-frequently and never took note of an anti-depressant after effect.
 

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NMDA antagonists aren't totally benign. Heavy use of ketamine and co. has resulted in permanent cognitive impairment in some users. I definitely haven't been the same since my daily K use, along with DXM, N20, etc..
 

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NMDA antagonists aren't totally benign. Heavy use of ketamine and co. has resulted in permanent cognitive impairment in some users. I definitely haven't been the same since my daily K use, along with DXM, N20, etc..
Agreed, but heavy use of anything is rarely a good idea. Even drugs as physically benign as LSD or marijuana can create problems with constant use. I've seen a lot of research about the neuroprotective effects of DXM (even against physical trauma, like a car accident, DXM seems to protect brain cells.) I've never seen anything demonstrating neurotoxicity at reasonable doses... except for that one infamous article, which the author later retracted.

I've never used K on a daily basis (or any other drug for that matter), but it was one I particularly enjoyed... such a pure and clean dissociative that just abolished all the problems of the real world. However, I stopped with the dissociatives a few years ago because I'm already a very isolated person, and the degree of isolation that K, or any dissociative, gives makes everything bleak. Maybe I wasn't using the correct doses that have been used in studies.

I've done DXM 4-5 times. While I liked doing LARGE amounts of K, I went all the way to the 4th plateau and it was just chaos. I preferred a smaller dose around the 2nd plateau. It would give me an afterflow the next day that made me feeling absolutely amazing though, so maybe I have experienced the anti-depressant effects of an NMDA antagonist. I stopped doing that years ago too, for that isolation reason above, not to mention it's a fairly "dirty" drug, targeting all kinds of receptors, and the restless stimulation during the comeup was harder for me to handle than the inevitable puking.
 

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I'm one of those people who can take bagfuls of OTC medications and feel no better or worse for it. I'm not sure if someone suggested Nyquil above - I've tried this before and it did nothing but make my mouth taste like syrup, didn't even make me slightly drowsy. The only thing I've encountered that's helped somewhat with anxiety was taking OTC sleeping pills - not even sure what the active ingredient was, but they're basically available at any drugstore, Walmart or Target.This is I'd have to take about ten times the normal dose to feel the effects: anxiety would diminish, but partly because I felt so zoned out that I didn't have the capacity to be anxious anymore.
There's two main kinds of OTC sleep aids. The natural/herbal stuff (ie melatonin, valerian, etc), which is only weakly effective, and sedating antihistamines (generally Benadryl or doxylamine succinate.)

The antihistamines are usually much more effective at sedation. However, that's exactly what is in Nyquil, and I suspect what was also in the OTC sleeping pills. The difference is probably the fact that you took a lot more. They don't work very well for me as they make me really uncomfortable, whereas prescription sleep aids are, believe it or not, more gentle.

If you are indeed taking an antihistamine, be careful with your high usage. At high doses these drugs are deliriants and can cause hallucinations for up to more than a day. Not the fun kind of LSD hallucinations either, but ones you're unaware of, where you can see and have a conversation with someone who's not actually there. Hallucinations of this nature can obviously be very dangerous, so just be careful.
 

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There's two main kinds of OTC sleep aids. The natural/herbal stuff (ie melatonin, valerian, etc), which is only weakly effective, and sedating antihistamines (generally Benadryl or doxylamine succinate.)

The antihistamines are usually much more effective at sedation. However, that's exactly what is in Nyquil, and I suspect what was also in the OTC sleeping pills. The difference is probably the fact that you took a lot more. They don't work very well for me as they make me really uncomfortable, whereas prescription sleep aids are, believe it or not, more gentle.

If you are indeed taking an antihistamine, be careful with your high usage. At high doses these drugs are deliriants and can cause hallucinations for up to more than a day. Not the fun kind of LSD hallucinations either, but ones you're unaware of, where you can see and have a conversation with someone who's not actually there. Hallucinations of this nature can obviously be very dangerous, so just be careful.
IMO It's unfortunate that Benadryl and doxylamine succinate have anticholinergic activity, otherwise they'd be fairly decent sleep meds. I just personally can't stand anticholinergics.
 

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IMO It's unfortunate that Benadryl and doxylamine succinate have anticholinergic activity, otherwise they'd be fairly decent sleep meds. I just personally can't stand anticholinergics.
I think a lot of what people attribute to anticholinergics is really an antihistamine effect. Maybe it's just my own personal bias as I had made that mistake in the past, but since then I think I have tried enough drugs to get some sense of the differences.

The anticholinergic effects of the nortriptyline I'm on, for instance, give me dry mouth, difficulty urinating (I feel like an old man!) and constipation. It does have an overall "feeling" to it but nothing, in my opinion, compared to drugs that have antihistamine effects on the CNS.

That being said, I agree with you. Which is one of the reasons I make sure my doctor keeps me supplied with hydroxyzine instead, which is also a first-gen antihistamine capable of crossing the BBB, but with a much smaller anticholinergic profile than the others. Interestingly enough, it's approved as an anxiolytic (although I don't find much effectiveness from it).

I do have actual seasonal allergies, with the symptoms being limited to intense full-body itching. Benadryl never did anything for me so I got myself a prescription after finding a study demonstrating that it took 75 times as much histamine to generate itching with hydroxyzine over Benadryl! That's huge. And it helps unbelievably well.

I also deal with kidney stones and other pain sometimes, and hydroxyzine is great for potentiating narcotic painkillers.

Sorry to be so long winded, but I love hydroxyzine :) If you're looking for a sedating antihistamine with the fewest anticholinergic effects, it's definitely the one to get, 50-100mg would be good, it's about as sedating as benadryl on a milligram by milligram basis, in my opinion. I'm not sure why it requires a prescription when Benadryl does not, but it's usually not hard to get a prescription for an antihistamine anyways :)

The only reason I don't use it regularly as a sleep med is the morning grogginess that seems to go hand in hand with all antihistamines when used as sleep aids.
 

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WHOA WHOA WHOA. Placebo is not weak. It will knock you out like a Frank Mir left jab right to the kisser.
Fixed it for you :)

Seriously though, melatonin has never helped me sleep even a bit. In combination with valerian though, I had some really bizarre nights with vivid dreams and even awareness of the rain hitting my window while sleeping. I drifted in and out of these states a lot, sort of half awake and half sleeping (not to be confused with lucid dreaming) and while it was an interesting experience, it simply wasn't restful.

On a tangent, I actually had my first lucid dream a few weeks ago (I literally pinched myself into awareness lol), but I found it impossible to control. It was kind of a nightmare too... I don't know why but it featured Glenn Beck :sus

Back on topic, it may be good for people with mild difficulty sleeping, but in terms of potency it can't even be compared with antihistamine or prescription sleep aids, it's just soooo much weaker.

I think the new melatonin agonists in development show some promise though.
 
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