Social Anxiety Support Forum banner

1 - 12 of 12 Posts

·
Registered
Joined
·
2,403 Posts
Discussion Starter · #1 ·
I thought some of you might find this interesting, I have never heard of this substance before:

In an experiment performed on rats, alpha-casozepine was administered at three different doses and compared against placebo and Diazepam (a benzodiazepine) in tests of anxious behavior. Not only was alpha-casozepine more effective than the placebo but also it was similar in activity to the drug in reducing Global Anxiety Score. Alpha-casozepine acted in a dose dependent manner. In other words, higher doses of alpha-casozepine were more effective at reducing anxiety than were lower doses.

Does alpha-casozepine offer any advantage compared to benzodiazepines? Animal studies have examined the safety of alpha-casozepine and have determined that it does not produce the side effects associated with benzodiazepines. Importantly, unlike benzodiazepines, alpha-casozepine doesn't impair memory, is not addictive, and does not produce tolerance (lose its effect over time).

Alpha-casozepine is found in nature in milk. Observing that warm milk has a calming affect on babies, researchers endeavored to isolate the active component. The first isolate was a milk protein hydrolysate (an enzymatically cleaved protein fraction). It was later discovered that alpha-casozepine was the peptide responsible for the anxiety-reducing affects of this milk protein fraction. Some research has used alpha-casozepine. Other research has used the milk protein hydrolysate (called Prodiet F 200) that contains it.

One animal study compared Prodiet F 200, St. John's Wort, Kava-Kava, Diazepam and saline solution as a control, for their ability to reduce anxiety. Global Anxiety Scores for the rats treated with Diazepam and Prodiet F 200 were significantly lower compared to the saline group. The rats given St. John's Wort and Kava-Kava did no better than the saline group. Prodiet F 200 reduced anxiety but these two popular herbs did not.
There have been two studies performed on humans using Prodiet F 200. Both human studies have found Prodiet F 200 to reduce measures of stress and anxiety.

In one experiment, Prodiet F 200 was studied in 42 men. They were divided into two groups of 21 each. One group received a skim milk placebo. The other group was given Prodiet F 200. The study was double-blind, meaning neither the test subjects nor the experimenters knew who was receiving which treatment. The day before the test, the test subjects took their assigned product with breakfast and with dinner. On the test day, they took it with a standard breakfast then underwent evaluation. Two different standard tests were done to assess the production of a stress response. One test was psychological in nature, the other more physical. The Stroop test is a challenging mental exercise that results in stress and anxiety. The cold pressor test stresses the nervous system by immersing the hand in cold (2° C) water. Stress response to these tests were assessed using measures of heart rate, systolic and diastolic blood pressure, as well as blood levels of the stress hormones ACTH and cortisol. Results of this study revealed that subjects taking Prodiet F 200 experienced less stress in response to both the Stroop test and the cold pressor test. Across the board, Prodiet F 200 was associated with lower heart rate, lower systolic and diastolic blood pressure, as well as lower levels of ACTH and cortisol. This study demonstrated the rapid onset of action of Prodiet F 200.
http://www.drdebe.com/destress.html

Research Studies: http://www.lactiumusa.com/research-study-reports.html

Available e.g. here: http://www.swansonvitamins.com/SWU369/ItemDetail

Lactium™ should act synergistically with other natural GABAergics like Valerian, L-Theanine, Niacinamide, Picamilon, Phenibut and Kava Kava.
 

·
crazy
Joined
·
2,067 Posts
i'd heard about milk opioids (casomorphins), but not casozepine. all kinds of interesting stuff in milk...
http://en.wikipedia.org/wiki/Casomorphin

some more on casozepine:

Zylkene/Lactium (alpha-casozepine)
I picked up a leaflet on this at the vet's the other day. It's a new anti-anxiety pill for dogs to help the cope with fireworks, moving house, seperation anxiety and other canine stressors. Obviously I wondered what was in it. Turns out it's concentrated peptide found in cow's milk, which binds to the GABA-A receptor and is superior to diazepam in some models of animal anxiety.
Lactium from Finland that contains the same active ingredient and is marketed for humans

Peptides isolated from the hydrolysate were examined for their affinity for the gamma -amino-butyric acid (GABA) type A receptor. Only one peptide, named alpha-casozepine, corresponding to the 91-100 fragment from bovine alpha (s1)-casein, expressed affinity for GABA(A) receptor.

http://www.dr-bob.org/babble/20080617/msgs/835962.html
 

·
Registered
Joined
·
1,936 Posts
Now we're going to need a prescription to buy milk :afr
 

·
Registered
Joined
·
2,403 Posts
Discussion Starter · #4 ·
Now we're going to need a prescription to buy milk :afr
A normal prescription won't get you milk as it has now to be considered a controlled substance. ;)

I really think that combining Lactium with one or more of the following substances could create a potent, natural & non-addictive tranquilizer with few side effects: L-Glutamine, L-Theanine, Valerian, Picamilon, Phenibut, Niacinamide, Kava Kava...
 

·
taking a break from SAS
Joined
·
1,408 Posts
From what I have read, this compound in its purest form (which I am not sure is available commercially) has some benzodiazepine type activity however, it has 10,000 times less affinity for GABA-A receptor compared to diazepam. It also lacks the disinhibition effects of benzodiazepines which may be a good thing.
In 1 study comparing Lactium to L-theanine, Lactium provides little more anxiolysis than high dose L-theanine. Not a very encouraging result since L-theanine barely provides any anxiety relief itself.
Overall, an interesting find but I have a hunch it is not much more effective than the GABAergic supplements already available and that it in no way approaches the effectiveness of benzos.
 

·
Registered
Joined
·
163 Posts
Animal studies have examined the safety of alpha-casozepine and have determined that it does not produce the side effects associated with benzodiazepines. Importantly, unlike benzodiazepines, alpha-casozepine doesn't impair memory, is not addictive, and does not produce tolerance (lose its effect over time).

This means it's either A) not very strong or B) a lie :)

Some day we will have non-addictive substances to cure anxiety and pain...............
 

·
Registered
Joined
·
2,403 Posts
Discussion Starter · #7 ·
Animal studies have examined the safety of alpha-casozepine and have determined that it does not produce the side effects associated with benzodiazepines. Importantly, unlike benzodiazepines, alpha-casozepine doesn't impair memory, is not addictive, and does not produce tolerance (lose its effect over time).

This means it's either A) not very strong or B) a lie :)

Some day we will have non-addictive substances to cure anxiety and pain...............
At least in animal studies it was as effective as diazepam. But as you and I haven't tested it, it's hard for us to say if it's weak or relatively strong. ;)
 

·
Banned
Joined
·
38,431 Posts
At least in animal studies it was as effective as diazepam.
Which to me is like saying "That car is as fast as any riding mower, topping out at damn near 10 mph!".
 

·
Registered
Joined
·
2,403 Posts
Discussion Starter · #9 ·
Interesting comparison, thanks.
 

·
Banned
Joined
·
38,431 Posts
Interesting comparison, thanks.
Valium isn't anything special. If you were to gather together a group of drug addicts who were into downers (we'll exclude the crowd that likes uppers) and you put in front of them every CNS depressant known to man how likely is it that they'd ever even get around to bothering with a benzo given so many more powerful choices?
 

·
Registered
Joined
·
2,403 Posts
Discussion Starter · #11 ·
Valium isn't anything special. If you were to gather together a group of drug addicts who were into downers (we'll exclude the crowd that likes uppers) and you put in front of them every CNS depressant known to man how likely is it that they'd ever even get around to bothering with a benzo given so many more powerful choices?
Having a low abuse potential is in fact a good thing and addiction is a bad thing. The higher the abuse potential of a substance the higher the risk of developing addiction with all it's consequences. The perfect anxiolytic should kill anxiety with no potential for abuse, dependence & addiction.
 

·
Registered
Joined
·
2,661 Posts
Valium isn't anything special. If you were to gather together a group of drug addicts who were into downers (we'll exclude the crowd that likes uppers) and you put in front of them every CNS depressant known to man how likely is it that they'd ever even get around to bothering with a benzo given so many more powerful choices?
Quite likely, benzos are popular drugs. With a high enough dose, they can knock you out for days, or give such powerful disinhibition that you act like a retard and run around the neighbourhood stark naked. They can easily give intoxication on the same level as drinking large quantities of alcohol (although there are differences). Tolerance changes this, obviously, as with most drugs.

If you're comparing them to drugs like GHB, it's not a fair comparison as GHB is not a "pure" CNS depressant and has stimulant-like effects too (via the GHB receptor). Without those stimulant effects, GHB would probably be as boring as baclofen, phenibut, etc.
 
1 - 12 of 12 Posts
Top