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Discussion Starter · #1 ·
Hey all, i'm back.

Some of you may remember me when I started nardil about 2 years ago...

Nardil changed my life. I was much less depressed and anxious, especially within the first 6 months..

It was so successful that I decided to pack up and move to Europe, where I now live today. I wanted to start a new life, and I would have never had the courage to do this without nardil. Before nardil even the thought of moving to the other side of the world would have made me anxious...

One thing I loved about nardil is that it gave me so much motivation to do things. This also gave me the motivation and courage to move to another country. I couldn't have done this without nardil.

Now after 2 years on 45mg I feel as though my life is good enough to come off it. I am tired of watching everything I eat, especially missing out on so many great foods in Europe! (eg cheese, sausage). I am also sick of the weight gain and insomnia which never completely went away. I woke up throughout the night every night.

I have tried to come off twice before (before I moved) and was unsuccessful (depression and insomnia returning). I was tapering at a rate of half a tablet every 2 weeks. However this time I am trying a quarter of a tablet each week, so its more gradual. I still expect it to be hard, but now that I have a better life, I'm hoping I can deal with it.

Good luck to others trying this miracle drug!
 

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Hey all, i'm back.

Some of you may remember me when I started nardil about 2 years ago...

Nardil changed my life. I was much less depressed and anxious, especially within the first 6 months..

It was so successful that I decided to pack up and move to Europe, where I now live today. I wanted to start a new life, and I would have never had the courage to do this without nardil. Before nardil even the thought of moving to the other side of the world would have made me anxious...

One thing I loved about nardil is that it gave me so much motivation to do things. This also gave me the motivation and courage to move to another country. I couldn't have done this without nardil.

Now after 2 years on 45mg I feel as though my life is good enough to come off it. I am tired of watching everything I eat, especially missing out on so many great foods in Europe! (eg cheese, sausage). I am also sick of the weight gain and insomnia which never completely went away. I woke up throughout the night every night.

I have tried to come off twice before (before I moved) and was unsuccessful (depression and insomnia returning). I was tapering at a rate of half a tablet every 2 weeks. However this time I am trying a quarter of a tablet each week, so its more gradual. I still expect it to be hard, but now that I have a better life, I'm hoping I can deal with it.

Good luck to others trying this miracle drug!
Hello my man ,

You have been on it for two years.. how much weight gain did you have ? what about sexual side effects.. did they continue as well ?

Do you think this drug is worth it ? I mean .. does it give you the courage for tough situations.. like asking a lady out and negotiating a raise or asserting yourself? craving social interaction etc...?

I will be having a psychiatrist appointment in probably two weeks.. and i want to talk Nardil... i have slight depression , but it is mainly my social phobia that is hindering me at work and socially . So the depression is actually a result of the social phobia itself.

Hope it goes well with your coming off.
 

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Hey all, i'm back.

Some of you may remember me when I started nardil about 2 years ago...

Nardil changed my life. I was much less depressed and anxious, especially within the first 6 months..

It was so successful that I decided to pack up and move to Europe, where I now live today. I wanted to start a new life, and I would have never had the courage to do this without nardil. Before nardil even the thought of moving to the other side of the world would have made me anxious...

One thing I loved about nardil is that it gave me so much motivation to do things. This also gave me the motivation and courage to move to another country. I couldn't have done this without nardil.

Now after 2 years on 45mg I feel as though my life is good enough to come off it. I am tired of watching everything I eat, especially missing out on so many great foods in Europe! (eg cheese, sausage). I am also sick of the weight gain and insomnia which never completely went away. I woke up throughout the night every night.

I have tried to come off twice before (before I moved) and was unsuccessful (depression and insomnia returning). I was tapering at a rate of half a tablet every 2 weeks. However this time I am trying a quarter of a tablet each week, so its more gradual. I still expect it to be hard, but now that I have a better life, I'm hoping I can deal with it.

Good luck to others trying this miracle drug!
NOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

DONT YOU ****ING COME OFF THE DRUG, IT ALWAYS GOES TO ****.

YOU CAN EAT WHATEVER YOU WANT, I HAVE DONE IT THE ENTIRE TIME ON NARDIL.

If you become resistant to nardil you will feel like the biggest idiot ever, I swear to god. Stay on this ****. You'll be ****ed up and on here 24/7 in a matter of weeks after going off of it. It NEVER ends well.

I ate cheese, sausage, small amounts of blue cheese, soy, all meats, lots of beer, alcohol. Basically anything. You just start with small tyramine based foods. Like I can't even believe you're coming off this amazing medicine when you haven't even tried eating the foods yet. You're not going to go hypertensive by testing out foods slowly with small amounts of tyramine. Almost nobody has a reaction to foods on Nardil, it's greatly overhyped. I think 5-10% have a problem with it. So start slow, and know the hypertensive symptoms.

Seriously man, don't go off this ****. You have no idea how lucky you are that you're in remission
 

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I wouldn't be influencing him like that. If I wanted to come off the meds I wouldn't want people telling me I shouldn't. I have it the opposite though. People tell me I shouldn't be on meds. People, you so silly.

Sometimes it just takes time to develop new coping skills. Over the course of my 4-5 years being on medication I have learned some new coping skills for anxiety. I have managed to reduce my clonazepam by 3/4 and am about ready to come off it completely. It's different now, anxiety doesn't affect me like it used to before I started medication.
 

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Discussion Starter · #5 ·
Hello my man ,

You have been on it for two years.. how much weight gain did you have ? what about sexual side effects.. did they continue as well ?

Do you think this drug is worth it ? I mean .. does it give you the courage for tough situations.. like asking a lady out and negotiating a raise or asserting yourself? craving social interaction etc...?

I will be having a psychiatrist appointment in probably two weeks.. and i want to talk Nardil... i have slight depression , but it is mainly my social phobia that is hindering me at work and socially . So the depression is actually a result of the social phobia itself.

Hope it goes well with your coming off.
Sexual side effects went away after about 3 months, gained about 15kg overall.

It was definitely worth it... I wouldn't have the life I do now if I didn't go on it. I now live in a country where i'm happier and have a lovely girlfriend. It doesn't make you "crave" social interaction any more than you normally would, it just makes it easier to do the things you want.
 

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Discussion Starter · #6 ·
NOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

DONT YOU ****ING COME OFF THE DRUG, IT ALWAYS GOES TO ****.

YOU CAN EAT WHATEVER YOU WANT, I HAVE DONE IT THE ENTIRE TIME ON NARDIL.

If you become resistant to nardil you will feel like the biggest idiot ever, I swear to god. Stay on this ****. You'll be ****ed up and on here 24/7 in a matter of weeks after going off of it. It NEVER ends well.

I ate cheese, sausage, small amounts of blue cheese, soy, all meats, lots of beer, alcohol. Basically anything. You just start with small tyramine based foods. Like I can't even believe you're coming off this amazing medicine when you haven't even tried eating the foods yet. You're not going to go hypertensive by testing out foods slowly with small amounts of tyramine. Almost nobody has a reaction to foods on Nardil, it's greatly overhyped. I think 5-10% have a problem with it. So start slow, and know the hypertensive symptoms.

Seriously man, don't go off this ****. You have no idea how lucky you are that you're in remission
Nardil isn't available in the country I now live. It has to be imported, and is extremely expensive.

My life is so much better here, so I am hoping that I will be able to manage without it. If not my plan is to try lyrica, which is also apparently great for anxiety.
 

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Sexual side effects went away after about 3 months, gained about 15kg overall.

It was definitely worth it... I wouldn't have the life I do now if I didn't go on it. I now live in a country where i'm happier and have a lovely girlfriend. It doesn't make you "crave" social interaction any more than you normally would, it just makes it easier to do the things you want.
How do you compare it to SSRI's? .. Was there no way to manage the weight gain .. like diet , excercise?
 

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Discussion Starter · #8 ·
How do you compare it to SSRI's? .. Was there no way to manage the weight gain .. like diet , excercise?
No comparison... SSRI's are ****. I tried every single SSRI without success. Nardil is the ONLY antidepressant that has worked for me.

You can manage the weight gain a little, but overall you'll probably still put on weight.
 

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You also have lamictal working on your anxiety you said. He'd be going on nothing I believe which is way different.

There is no chance that coming off Nardil will lead to a successful situation where your anxiety will be minimal like on nardil.

There are people that have milder amounts of anxiety and use benzos in the interim and can ween off them after practicing CBT. That's possible. But for people with major anxiety disorders that are crippling, you can't just come off Nardil and expect that you've "learned" tactics that will help you get by similarly as to being on Nardil.

You'll just be anxious, period.

Quotes from when I followed you back when I was using Nardil

"*sigh* I give up, nardil has beaten me." - 6 days after taking Nardil, so anxious that it almost made you stop the med.

"Looks like i'll be living the rest of my life with SA and depression. FML" - again 6 days into Nardil.

I remember you posted so often because of your anxiety that people thought you were a spam bot.

You had to constantly go up and down to find a therapeutic dose which took a lot of effort and time.

"Lately I've been enjoying my job more as well because it seems easier talking to people, sometimes even enjoyable." - 40 days in

"Yes, it has been life changing for me, but not to the extent I dreamed/hoped for. Maybe I was just hoping for too much? But put it this way, I have been going out at night and socialising pretty much every weekend. I have also been meeting lots of girls, and dating a new girl (sometimes two!) each week! I have also made a lot of new friends. " - like 4 months in

You just became so much better by using Nardil, and before you were constantly worried, posting here like 7 times a day worrying, and then you slowly stopped posting and then you started living.

Really, it's just a waste to throw that all away. The GABA-T will disinhibit and GABA will slowly decrease, you'll feel more worried and probably depressed as well. It's a dangerous road messing with something when it is working very well and is keeping you functional just so that you can eat certain foods.

You don't even know whether there is an issue with foods.

EDIT: Lyrica probably will not work. It will help initially but you will develop a tolerance and slowly have to use more and more until you max out then you will go through withdrawal which will be hell. The reason Nardil works is because it inhibits GABA-T, thus GABA is always at a higher level and there will be no building up a tolerance. The only thing is sometimes the entire med just stops working. But this isn't building up a tolerance.

EDIT2: AND FINALLY, "Forgot to reply to this thread after going back up to 45mg. I am now back on 45mg again and doing well. My biggest goal and motivation at the moment is to travel and move overseas. Nardil gives me the courage and focus to do this.

Whenever I try to come off the depression/anxiety always returns. This is how I know its working. Sometimes I forget how crap I used to feel before nardil.

As much as i'd like to be medication free, I think I'm going to have to stay on it until everything in my life is perfect (or close to it). Perhaps then I may be well enough to try and come off it again."


It doesn't matter how good your life is, how many friends you have, how much money you have, how well you're doing. Those things don't raise GABA levels. When you go off Nardil, GABA concentrations will fall and you will relapse.

Family members have tried to do this as well. These are inherent disorders. Using an EEG you can actually see that people with anxiety disorders have abnormal GABAa and GABAb levels. Probably something wrong with the vagus nerve, I have no idea. All I know is that everyone relapses, unless you replace it with something else.
 

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NOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO

DONT YOU ****ING COME OFF THE DRUG, IT ALWAYS GOES TO ****.

YOU CAN EAT WHATEVER YOU WANT, I HAVE DONE IT THE ENTIRE TIME ON NARDIL.

If you become resistant to nardil you will feel like the biggest idiot ever, I swear to god. Stay on this ****. You'll be ****ed up and on here 24/7 in a matter of weeks after going off of it. It NEVER ends well.

I ate cheese, sausage, small amounts of blue cheese, soy, all meats, lots of beer, alcohol. Basically anything. You just start with small tyramine based foods. Like I can't even believe you're coming off this amazing medicine when you haven't even tried eating the foods yet. You're not going to go hypertensive by testing out foods slowly with small amounts of tyramine. Almost nobody has a reaction to foods on Nardil, it's greatly overhyped. I think 5-10% have a problem with it. So start slow, and know the hypertensive symptoms.

Seriously man, don't go off this ****. You have no idea how lucky you are that you're in remission
maybe the reason Nardil failed for you was because you didn't follow the food restrictions.
 

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maybe the reason Nardil failed for you was because you didn't follow the food restrictions.
No, because it worked twice and I didn't follow the food restrictions.

It also worked the third time, it just pooped out really quickly and like I said, it may have been because I restarted it and developed a short term resistance, B6 might have destroyed Nardil making it useless, OR Nardil may just not work with me anymore.

There is no evidence to support disobeying the diet leads to Nardil being ineffective. It only states to stick to the diet to avoid tyramine build up because MAO-A inhibition lets tyramine build up which may cause a hypertensive reaction.
 

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No, because it worked twice and I didn't follow the food restrictions.

It also worked the third time, it just pooped out really quickly and like I said, it may have been because I restarted it and developed a short term resistance, B6 might have destroyed Nardil making it useless, OR Nardil may just not work with me anymore.

There is no evidence to support disobeying the diet leads to Nardil being ineffective. It only states to stick to the diet to avoid tyramine build up because MAO-A inhibition lets tyramine build up which may cause a hypertensive reaction.
ive been following your Nardil progress since day 1. i don t remember you had a single day without horrible Ses. so....saying that it worked for you its kinda of not true.
 

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side effects? Yeah I did have side effects, but it helped the depression and the anxiety so I could go out. Then the side effects began to get worse and the effect stopped working.

I've trialed Nardil 3 times. I've never had those side effects ever at 45 mg. Something went wrong, and I'm not going to spend time proving what went wrong, because I can't.

My second trial I had the efficacy of depression and anxiety reduction with pretty much the only SE being constipation at 45 mg.

Why on the 3rd trial did I have side effects I experience at 60 mg? I have no idea.
 

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Discussion Starter · #14 ·
It's not a wise idea to get too cocky about the food restrictions... Sure you might be fine 98% of the time, but it's that 2% of the time that could give you a stroke or worse. I have always been extremely careful with the restrictions because it's just not worth the risk. If you ignore all food restrictions then you WILL get a severe hypertensive crisis one day if you're on Nardil long term.

Even with being careful I have still had 2 mild reactions with things I didn't even realise.

It's not just the food restrictions i'm worried about. It's also if I were ever in an accident or required urgent surgery, dental work with anesthesia etc.
 

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It's not a wise idea to get too cocky about the food restrictions... Sure you might be fine 98% of the time, but it's that 2% of the time that could give you a stroke or worse. I have always been extremely careful with the restrictions because it's just not worth the risk. If you ignore all food restrictions then you WILL get a severe hypertensive crisis one day if you're on Nardil long term.

Even with being careful I have still had 2 mild reactions with things I didn't even realise.

It's not just the food restrictions i'm worried about. It's also if I were ever in an accident or required urgent surgery, dental work with anesthesia etc.
You're not just going to have a stroke. Your BP will steadily rise after eating whatever and you will develop a headache and some neck stiffness/pain and you immediately go and find the closest ER.

There have been plenty of users on crazymeds, here and dr-bob's forums that have used it for many years and don't have this issue.

This is probably an issue with your GAD since you were most worried about this even before starting Nardil. Probably had a panic attack rather than a mild hypertensive crisis after eating something, since your head was probably like... OH ****TT, I CANT BELIEVE I ATE THAT.

Maybe we are being a bit careless, but we don't worry excessively about something that has a very small % chance, and even smaller if we've tested out the foods and they're fine. They don't even mildly raise my BP.

Honestly, it doesn't bother me whether you stay on or go off your meds. I usually never interject with peoples decisions. It just looks from my POV that you have done MUCH better being on Nardil and IMO these gains are going to be erased if you totally go off Nardil
 

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I fully agree with the previous posters who suggested you should stay on Nardil.
I understand that weight gain and insomnia are annoying side effects, but as long as they don't seriously interfere with your daily functioning, you better carefully weigh up what's the lesser of the evils...the side effects or crippling depression and anxiety. Actually it's an easy choice.
Keep in mind that Nardil is a very powerful drug, the sledgehammer among the antidepressants which carpet bombs a host of neurotransmitters. Expect that you developed significant tolerance at all receptor sites of these neurotransmitters. Withdrawing from Nardil will likely make you fall into a deep hole and make you experience pure biochemical depression, and anxiety. Even all the coping skills you have learnt while on Nardil won't help you much in a situation where your neurotransmitters are completely out of whack.
You already attempted withdrawing before and you always felt like crap. Why should things be different this time? I'm afraid you will find yourself immensely depressed and with crippling anxiety somewhere in Europe. All the friends you made and girls you dated will probably be very irritated by your changed personality.
Of course you can always go back on the drug, but it will arguably take a while until you feel the full effect again. Also you wouldn't be the first for whom a drug pooped out after first withdrawing and thereupon reintroducing it again.

I think your ongoing "high" on Nardil distorts your perspective. Enjoy the life that this drug enabled you to live. Don't gamble with your sanity.
 

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I fully agree with the previous posters who suggested you should stay on Nardil.
I understand that weight gain and insomnia are annoying side effects, but as long as they don't seriously interfere with your daily functioning, you better carefully weigh up what's the lesser of the evils...the side effects or crippling depression and anxiety. Actually it's an easy choice.
Keep in mind that Nardil is a very powerful drug, the sledgehammer among the antidepressants which carpet bombs a host of neurotransmitters. Expect that you developed significant tolerance at all receptor sites of these neurotransmitters. Withdrawing from Nardil will likely make you fall into a deep hole and make you experience pure biochemical depression, and anxiety. Even all the coping skills you have learnt while on Nardil won't help you much in a situation where your neurotransmitters are completely out of whack.
You already attempted withdrawing before and you always felt like crap. Why should things be different this time? I'm afraid you will find yourself immensely depressed and with crippling anxiety somewhere in Europe. All the friends you made and girls you dated will probably be very irritated by your changed personality.
Of course you can always go back on the drug, but it will arguably take a while until you feel the full effect again. Also you wouldn't be the first for whom a drug pooped out after first withdrawing and thereupon reintroducing it again.

I think your ongoing "high" on Nardil distorts your perspective. Enjoy the life that this drug enabled you to live. Don't gamble with your sanity.
Some how i find this making sense.. even though i hate the idea of having to depend on a drug for life. I am due to meet a doctor and i will talk about Nardil there.
 

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No comparison... SSRI's are ****. I tried every single SSRI without success. Nardil is the ONLY antidepressant that has worked for me.

You can manage the weight gain a little, but overall you'll probably still put on weight.
So, did you exercise on a regular basis including cardio. (cycling, jogging etc) and sill put on the weight?
Or were you not exercising on a regular basis?
 

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So, did you exercise on a regular basis including cardio. (cycling, jogging etc) and sill put on the weight?
Or were you not exercising on a regular basis?
I would also really like to know this, gaining 15kg wouldn't be terrible but it's still a fair bit of weight to gain if your exercising every day, almost seems impossible to gain that much if you do work out every day, healthy diet and so on.

If you could maybe give some more precise information on this, like did you work out at the beginning and did the weight stay off.

If not how much where you working out or would you say once you where feeling better you sort didn't bother so much, hell did you work out at all, if not then 15kg seems a fair trade indeed.

I just can't Imagine working my *** off every day and gaining 15kg that would suck.

This is my last chance saloon so if and when I take it I want to be prepared.

Thanks in advance.
 
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