I took ashwagandha for a while, and did feel calmer and more stable! But I didn't really notice this until I ran out. After it was gone, about a week or so without it, I felt irritable, snappy, tired... the works. It is definitely on my to do list to get some more of this!
This post interested me in finding out if there was anything to this experience. Wikipedia states:
The main active constituents [in ashwagandha] are alkaloids and steroidal lactones. These include tropine and cuscohygrine. The leaves contain the steroidal lactones.
So are tropine and cuscohygrine going to tell us anything about the above candy's experience? Let's look if cuscohygrine tells us anything first:
Cuscohygrine is a pyrrolidine alkaloid found in coca. It can be extracted from plants of the family Solanaceae... ...Cuscohygrine usually comes with other, more potent alkaloids like atropine or cocaine.
Pyrrolidine is found naturally in the leaves of tobacco and carrot. The pyrrolidine ring structure is present in numerous natural alkaloids such as nicotine and hygrine. It is found in many pharmaceutical drugs such as procyclidine and bepridil. It also forms the basis for the racetam compounds (e.g. piracetam, aniracetam)."
So there is probably something going on there; but what about tropine?
also a antichlogeric agent -
Anticholinergics are a class of medications that inhibit parasympathetic nerve impulses by selectively blocking the binding of the neurotransmitter acetylcholine to its receptor in nerve cells. The nerve fibers of the parasympathetic system are responsible for the involuntary movements of smooth muscles present in the gastrointestinal tract, urinary tract, lungs, etc
I'm not sure what effect this has on choline supplements... does anyone know?
I think the majority of the health benefits likely come from the withaferin A, or steroidal lactones. The anxylotic effects probably come from the tropine and cuscohygrine. Does long-term ingestion of tropine and cuscohygrine cause withdrawal symptoms following discontinuation of use?