I don't think the depression and anxiety I experience is ever bad enough for me to take prescribed medicines, so I though St John's wort was exactly what I needed. The leaflet advises not to take SJW if you have a clinical, diagnosed depressive illness.
There's been a few occasions where I have taken SJW when I feel really anxious or so low in mood that I feel like I can't get through the day with a huge burden on me. I am well aware of placebo effects, but I have to say that I have found a positive effect with SJM from the first tablet. Within a few hours, I feel the burden lift and I feel full of vigour. I don't think this is a placebo effect as I also recognise a slightly unwanted effect too - a dry mouth and a slight headache.
I have been feeling really anxious and low for about five weeks and then remembered SJW. I bought some today in Tesco and thought that it was too cheap to work this time. A couple of hours later, I felt transformed. I had been lying on my bed, not knowing how I could go to work in the morning. I felt so detached and brain dead. I'm now feeling absolutely great with a real buzz. I really don't thin it is placebo. It's a huge relief from a month of heavy stress and anxiety.
So, it might not work if you are seriously, clinically depressed, but if you are like me, I would say it is well worth a try.