It's been a good while since I posted here on SAS, been busy with school & work so haven't had much time to contribute.
Still taking Nardil, at this point in time it's been two years and a month on the drug. My viewpoint these days of it is that it helps me still staying focused and calmer somewhat in all aspects of my life, as it keeps me positive and looking ahead versus ruminating on things long since passed (a big issue for me prior to being on medication).
However; I will say that without a doubt, after being on 60mg for these two years it has definitely reached it's peak of effect and leveled out so greatly that to some extent I might even go as far to say I'm only being 'helped' possibly 25-30% by it's actions. The old carefree sociability and sense of wonder first experienced has faded, leaving behind a static benefit of treading water just above the horizon of a depressive state.
As such, I'm currently looking into alternative options. This post is not meant to discourage anyone from beginning on Nardil or an MAOI! Rather, that Parnate overall might be a more-suitable first try... and that also, if you have a positive response from Nardil as I did, utilize the year's worth or so of maximum effect from it to start building a social group and bonds with people to have a close circle of support when the benefit may lessen. I'm happy to say that I've got a great group of close friends now in my life who are there for me throughout struggles, be it anything from the trials of college education or dealing with romantic relationships. The beauty of Nardil is it sort of frees your mind from the viewpoint of people constantly judging your words & actions (at least, that's what it did for me). I started seeing more and more clearly how people in today's society are no less perfect than I am. An open mind is key to making attachments.
Anyways I'm rambling at this point, apologies. It may sound ridiculous or far-fetched, but at some point this upcoming year (2016) my plan is to get off Nardil and begin utilizing more 'as-needed' solutions, such as Kratom and Kava, which from my personal experiences can be used to great effect as anxiolytics and mood brighteners without many downsides, if any at all. This, in conjunction with other supplements such as L-Carnitine injections (first learned about from DatBTrue as a means of enhancing mood through modulation of serotonin and dopamine, as well as being a great workout adjunct for building muscle), occasional usage of Marijuana with friends, perhaps some mild attempts at psychedelic usage for introspection, etc. Just living life overall, honestly.
I believe Nardil and MAOIs/antidepressants in general are a great tool to be used when needed. It's just that in my own usage, I've experienced a lessening of effect over time and found other things which seem to work better for myself.
I'm convinced after reading through countless articles on PubMed, and hearing lectures on the subject that many cases of depression (NOT ALL, but many subtypes) is due to inflammation in the body/brain.
I HIGHLY recommend those of you who wish to look into it further read the NCBI study called Is Depression an Inflammatory Disorder? --> http://www.ncbi.nlm.nih.gov/pubmed/21927805
Microdoses of psychedelics such as LSD and psilocybin have also caught my eye recently. A good deal of papers and studies conducted are revealing just how effective they can be for treating anxiety and depression; as well as of course Ketamine and ayahuasca.
Long story short; MAOIs work extremely well for at least a period of time, perhaps much longer-term for some than I experienced. But they are not the only option! So don't be afraid to explore and find what works for you