1mg of risperdal OR 150 mgs of seroquel.
out of these 2, which is stronger at blocking dopamine stimulation?
Hi, hands down, risperdal. Yes, seroquel knocks you out at 150 mg, but that's because of its antihistamine and antiserotonergic effect.
At 150 mg the amount of D2 blockade is negligible. Significant D2 blockade from seroquel begins at 300-400 mg.
In the case of risperdal, which is less sedating than quetiapine, begins to block significant amount of D2 receptors from 1-2 mg.
In the case of AP, more sedating doesn't always mean stronger and many times is the opposite, look for example at haloperidol (not so sedating but potent) vs. chlorpromazine (weak but very sedating).
Bipolar II, social anxiety, assorted brain cooties.
What keeps me at bay:
Quetiapine 200 mg
Lamotrigine 200 mg
Venlafaxine 150 mg
Propranolol 80 mg
Non-mental issues: Hypertension, inoperable pilonidal cyst, IBS, seasonal allergy.
PRN: Pregabalin 300 mg, clonazepam 0.5 mg, tramadol 50 mg, dextropropoxyphene/ibuprofen 100/400 mg, antihistamines in spring and autumn (diphenhydramine, cyproheptadine, clopheniramine).