Can you provide a source for those studies please Ehsan?
i've used the following paper for nardil. it's one of the latest papers published considering nardil in SAD by well-known scientist Liebowitz:
Cognitive behavioral group therapy vs phenelzine therapy for social phobia: 12-week outcome.
a comparison between nardil and meclebomide in SAD:
Pharmacotherapy of social phobia. A controlled study with moclobemide and phenelzine
these are papers i've used for Sertraline for example:
MULTIDIMENSIONAL EFFECTS OF SERTRALINE IN SOCIAL ANXIETY DISORDER by Kathryn M. Connor, M.D., Jonathan R.T. Davidson, M.D., Henry Chung, M.D., Ruoyong Yang, Ph.D., and Cathryn M. Clary, M.D.
Sertraline Treatment of Generalized Social Phobia:A 20-Week, Double-Blind, Placebo-Controlled Study
by Michael A. Van Ameringen et al
Thing is that it has been well documented that pharmacetical companies run several trials on a given drug, manipulating the time, dose, and methodology and then pic the ones that have the most robust response for publication.
I met a medical student once who ghost wrote research articles for well know professors and the like to sign off on and I don't doubt that Pharmacetical companys would use viral marketing techneiques for any new drug loading up forums with positive reviews.
Antidepressants 'no better than placebo' - February 26, 2008
I'm not sure you can take any study at face value with antidepressants being such big business these days
i know that these methods are already used by many ones(i've seen myself in the field of engineering) to write new papers but we shouldn't suspect all papers.
anyway, many people respond to their firs meds and there isn't any reason for them to come to forums. on the other hand, many few ones try nardil and it isn't available in many countries. i think MAOIs have a higher response rate but they don't abolish SAD. we need better combination
it is known that HPA axis and CRF are highly related to all anxiety and depression disorders but nardil can't affect CRF or many other factors involved in SAD.
When an organism is under stress, or perceives itself under stress, the hypothalamus secretes corticotropin-releasing hormone/factor (CRH/CRF). CRH/CRF in turn increases secretion of adrenocorticotrophic hormone (ACTH) from the anterior pituitary. ACTH in turn stimulates the release of glucocorticoids from the adrenal cortex. Persistent, uncontrolled physical and psychosocial stress causes excess cortisol secretion from the adrenal glands. Excess cortisol causes dendritic shrinkage in the hippocampus and a contrasting growth of dendrites in the lateral amygdala. These stress-induced changes tend to lower mood; they can cause clinical depression in the genetically vulnerable.
unfortunately, there isn't any miracle drug for SAD. we should separate what one drug can do and what it can't do.
what nardil can do:
1)inhibit MAO-A and MAO-B so increase Dopamine, Serotonin, GABA and trace amines(reduces NE activity)
2) it slightly releases Dopamine which is pleasant and help sociability.
what nardil can't do:
1) to agonize or antagonize receptor subtypes selectively. for example 5-ht2 antagonists are shown to decrease anxiety and depression while 5-ht1 agonists decrease anxiety.
2)to affect many hormones(oxytocin,...), neuropeptides(CRF,...), receptors(NMDA,...), neurotransmitters(Glutamate, ...), enzymes, ... involved in SAD or other mental disorders.
nardil can help many ones who haven't responded to simple selective antidepressants but there is many other combos to try for who want better results or who haven't responded to nardil.