Medications that does not make you flat/apathetic - Social Anxiety Forum
 
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post #1 of 14 (permalink) Old 07-24-2019, 12:35 PM Thread Starter
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Medications that does not make you flat/apathetic


Ive tried Effexor, Celexa and Cipralex. Neither was very effective, effexor working the best, and they caused me to never feel happy, exited or connected to others. Im struggling, and really need to go on medications again. Any tips?
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post #2 of 14 (permalink) Old 07-24-2019, 09:33 PM
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Serotonergic drugs can cause numbness because they antagonize dopamine.
Maybe try a lower dose, a study said that lower dose are as or even more effective and tolerable than high doses.
Or maybe you could try non-SSRI drugs
Nardil, klonopin...
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post #3 of 14 (permalink) Old 07-25-2019, 02:50 AM
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^^ what Hopeforall said is good advice.

For me, Nardil = zero social anxiety + normal emotions, no SSRI numbness.

IMO it's worth at least trying.
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post #4 of 14 (permalink) Old 07-25-2019, 11:58 AM Thread Starter
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Thank you both! Does the Serotonergic medications lower dopamin? Would Wellbutrin added on help with this? Im really interested in Nardil, but Im not sure they would ever describe it here. Im going to my psychiatrist in a couple of weeks and Im feeling that I have to make a decision until then.
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post #5 of 14 (permalink) Old 07-25-2019, 12:24 PM
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Quote:
Originally Posted by Johansen Maria Stine View Post
Thank you both! Does the Serotonergic medications lower dopamin? Would Wellbutrin added on help with this? Im really interested in Nardil, but Im not sure they would ever describe it here. Im going to my psychiatrist in a couple of weeks and Im feeling that I have to make a decision until then.
5ht2C receptors lower dopamine if you are given a high dose.
That's why SSRI tend to be energizing at lower doses and sedating at high doses.
A lower dose can fix this
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post #6 of 14 (permalink) Old 07-25-2019, 03:29 PM
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bupropion addon small dose (or instead of the SSRI) would maybe do it, if available in your country. Have to swim through a sea of terrified but slightly confused medics in the UK to prescribe it though.

This is off the top of my head, so *please* research it, I haven't, its just an idea.. but would pretending you have restless legs, and getting dopaminergic treatments (Ropinerole etc) for that help? I was surprised that a GP just randomly prescribed this for me when I had restless legs. But be v careful with dopaminergic meds.

You have other options med wise as well..

Bupropion, as mentioned
Moclobemide (eh worth a shot its relatively side effect free)
Maybe some tricyclics have more energising profiles?
Nardil / Parnate if you can get (probably the latter if poss)
Agomelatine (liver checks)

There might be a few others, I haven't really kept up with meds.

Dimethylamidophenyldimethylpyrazolone
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post #7 of 14 (permalink) Old 07-25-2019, 11:07 PM Thread Starter
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Hopeforall: I had no idea! I can't understand why doctors dont give their patients this info. I've got more info here than ever by my doctors..

Splendidbob:
Bupropion is easy to get here luckily, I was thinking the same as you! I also been struggling with restless legs the last couple of weeks so it might be good for both. Nardil is what I would most like to try, but I have my doubts that they will.

Thank you again both of you! 🙂
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post #8 of 14 (permalink) Old 07-31-2019, 05:42 AM
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Theoretically an SSRI's numbness should be blocked by a 5HT2C antagonist, such as mianserin, mirtazapine, or a low dose of amoxapine or asenapine. Of course your doctor won't know this, but you could possibly obtain one of these drugs from a second doctor.

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post #9 of 14 (permalink) Old 07-31-2019, 07:10 AM
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Quote:
Originally Posted by Johansen Maria Stine View Post
Hopeforall: I had no idea! I can't understand why doctors dont give their patients this info. I've got more info here than ever by my doctors..

Splendidbob:
Bupropion is easy to get here luckily, I was thinking the same as you! I also been struggling with restless legs the last couple of weeks so it might be good for both. Nardil is what I would most like to try, but I have my doubts that they will.

Thank you again both of you! 🙂
Missed this reply (stick an @ before the name and it tags us ).

Doctors are funny. GP's generally don't know this stuff. Psych doctors might, but eh, i dunno. I don't actually want to badmouth doctors, because they have access to the official info and it is what it is. The problem with the internet is, people who don't really know their **** pretend like they do (like me). Or parrot info from other sources that aren't reliable. You can't tell who is looking at actual research online (very very few, in a systematic way), and who has the capabilities to understand that information (very very fewer).

Nonetheless, bupropion is a standard adjunct to SSRI treatment, I am sure if its available where you are they will prescribe a low dose to try.

Re restless leg syndrome, if you have that, check iron.

Dimethylamidophenyldimethylpyrazolone
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post #10 of 14 (permalink) Old 07-31-2019, 02:59 PM
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Quote:
Originally Posted by GregW View Post
Theoretically an SSRI's numbness should be blocked by a 5HT2C antagonist, such as mianserin, mirtazapine, or a low dose of amoxapine or asenapine. Of course your doctor won't know this, but you could possibly obtain one of these drugs from a second doctor.
Welcome back Greg 🙂
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post #11 of 14 (permalink) Old 07-31-2019, 07:40 PM
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Quote:
Originally Posted by SplendidBob View Post

This is off the top of my head, so *please* research it, I haven't, its just an idea.. but would pretending you have restless legs, and getting dopaminergic treatments (Ropinerole etc) for that help? I was surprised that a GP just randomly prescribed this for me when I had restless legs. But be v careful with dopaminergic meds.

You have other options med wise as well..

Bupropion, as mentioned
Moclobemide (eh worth a shot its relatively side effect free)
Maybe some tricyclics have more energising profiles?
Nardil / Parnate if you can get (probably the latter if poss)
Agomelatine (liver checks)

There might be a few others, I haven't really kept up with meds.
Whatís your experiencia with Ropinirole? . There is no much information in psichiatry Use.
Even though those kind of meds hit dopamine receptor, theyíre not recreational so you donít have worry about addiction. At least, thatís what i Heard.
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post #12 of 14 (permalink) Old 08-01-2019, 02:05 AM
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Psychedelics.

empathogens.

Benzos and other muscle relaxants (usually slight euphoric effects from these)
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post #13 of 14 (permalink) Old 08-05-2019, 09:56 PM
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CBD oil, you'll have dry mouth but you won't be apathetic.

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post #14 of 14 (permalink) Old 08-05-2019, 11:46 PM
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CBD oil, you'll have dry mouth but you won't be apathetic.
I find it makes me very lethargic and lazy just like thc does. Only without the head high.
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