Future antidepressants/anti anxiety medications - Social Anxiety Forum
Reply
 
Thread Tools
post #1 of 34 (permalink) Old 07-28-2015, 03:55 PM Thread Starter
SAS Member
 
Join Date: Aug 2010
Location: California
Gender: Male
Age: 30
Posts: 851

Future antidepressants/anti anxiety medications


Are there any promising medications that are going through trials or being developed?

When are they going to have a medication that acts like alcohol without all the bad side effects and dependency issues?
Iwillovercomeanxiety1 is offline  
Sponsored Links
Advertisement
 
post #2 of 34 (permalink) Old 07-28-2015, 06:44 PM
SAS Member
 
Join Date: Jul 2015
Posts: 69
Unfortunately, the vast majority of "promising" treatments turn out not to work. The best stuff we currently have is decades-old.

Parnate 30mg

In the past: Luvox, Prozac, Paxil, Effexor, Remeron, Lamictal, Atenolol, Propanolol, Neurontin, Buspar, Klonopin, Valium, Xanax, Imipramine, Adderall, Dexedrine, Ritalin, Concerta, Strattera, and others. With either no or minimal effect.
DesperateGuy is offline  
post #3 of 34 (permalink) Old 07-28-2015, 08:18 PM
You can do this!
 
Caedmon's Avatar
 
Join Date: Dec 2003
Location: Cascadia
Gender: Male
Age: 38
Posts: 4,464
My Mood: Cheerful
Only two things I know of that sound promising are:

- ketamine
https://en.wikipedia.org/wiki/Ketamine#Depression

- opioid agonist/modulator thingy ALKS 5461
http://www.medscape.com/viewarticle/805197

"Everything old is new again"

Medication-related posts are for brainstorming purposes only. Talk to your doctor.

My meds: Parnate, Lamictal, Wellbutrin, trazodone
Caedmon is offline  
 
post #4 of 34 (permalink) Old 07-28-2015, 08:32 PM Thread Starter
SAS Member
 
Join Date: Aug 2010
Location: California
Gender: Male
Age: 30
Posts: 851
Quote:
Originally Posted by Caedmon View Post
Only two things I know of that sound promising are:

- ketamine
https://en.wikipedia.org/wiki/Ketamine#Depression

- opioid agonist/modulator thingy ALKS 5461
http://www.medscape.com/viewarticle/805197

"Everything old is new again"

How soon could those possibly be out? Is there any way to get Ketamine prescribed right now?
Iwillovercomeanxiety1 is offline  
post #5 of 34 (permalink) Old 07-29-2015, 01:35 AM
Permanently Banned
 
Join Date: Nov 2003
Location: Milwaukee, WI (BDSM sadist, Libertarian)
Gender: Male
Age: 47
Posts: 38,433
Quote:
Originally Posted by Iwillovercomeanxiety1 View Post
How soon could those possibly be out? Is there any way to get Ketamine prescribed right now?
Ketamine is a C-III controlled substance, so I can't think of any reason why a compounding pharmacy could not make ketamine pills or injections if a doctor were willing to write the script.

Of course, ketamine vials for injection already exist. Vets have cabinets full of them.
UltraShy is offline  
post #6 of 34 (permalink) Old 07-29-2015, 05:36 AM
SAS Member
 
mikoy's Avatar
 
Join Date: Aug 2010
Location: Poland
Gender: Male
Age: 35
Posts: 327
I have tried ketamine in infusions and I'm totally disappointed. I'm waiting for ALKS 5461
- it's on III stage of trials.
mikoy is offline  
post #7 of 34 (permalink) Old 07-29-2015, 02:04 PM
Tired
 
SplendidBob's Avatar
 
Join Date: May 2014
Location: UK
Language: English
Gender: Male
Posts: 11,615
Quote:
Originally Posted by Caedmon View Post
- opioid agonist/modulator thingy ALKS 5461
http://www.medscape.com/viewarticle/805197
Yup, https://en.wikipedia.org/wiki/ALKS-5461 looks damn interesting.
SplendidBob is offline  
post #8 of 34 (permalink) Old 07-29-2015, 03:41 PM
SAS Member
 
fotschi's Avatar
 
Join Date: Feb 2015
Location: United States
Gender: Male
Posts: 623
No way is ketamine going to be used. Too much abuse potential. I'd abuse the **** out of it myself if MXE wasn't cheaper.

ALKS 5461 sounds fun but does not sound like a good idea. I'd take it.

NRX-1074 is what I'm interested in. I just hope me taking a ****load of MXE isn't gonna mess up its ability to work when I can get my hands on some...

.`..`..`..`.
fotschi is offline  
post #9 of 34 (permalink) Old 08-03-2015, 08:39 AM Thread Starter
SAS Member
 
Join Date: Aug 2010
Location: California
Gender: Male
Age: 30
Posts: 851
When is Ketamine expected to be on the market?

Any other promising anxiety meds?

Where do you go to see future meds that are set to be out soon?
Iwillovercomeanxiety1 is offline  
post #10 of 34 (permalink) Old 08-03-2015, 05:42 PM
Phucked
 
TheoBobTing's Avatar
 
Join Date: Jul 2010
Location: United Kingdom
Gender: Male
Age: 32
Posts: 739
On the anxiety front, I don't expect much progress in the next few years. On the depression front, with a bit of luck we might see some genuine advances in the coming years. ALKS-5461 is novel, and looks like it might be reasonably effective. Also, Naurex may have tapped some or all of the potential of ketamine with GLYX-13 and NRX-1074. ALKS-5461 will hopefully be approved in 2016, and the others perhaps two-to-four years later. I believe ALKS-5461 and GLYX-13 have been fast-tracked by the FDA, and that there is reason to believe NRX-1074 stands a good chance of being fast-tracked.

I remember people going on about triple-reuptake inhibitors a while back. I believe that they are not progressing so well.

I have tried sh*talopram, belowpar, diazesham, noshowmazine, lorazesham, Cynica, Ineffexor, crapranolol, futileoxetine and Depascrote without success.

I am now just using CBT.
TheoBobTing is offline  
post #11 of 34 (permalink) Old 09-17-2015, 09:46 AM Thread Starter
SAS Member
 
Join Date: Aug 2010
Location: California
Gender: Male
Age: 30
Posts: 851
What's suppose to be the most promising medications in the works for anxiety? Is Ketamine and Buprenorphine suppose to be good for anxiety?
Iwillovercomeanxiety1 is offline  
post #12 of 34 (permalink) Old 09-18-2015, 11:05 PM
SAS Member
 
Join Date: Jun 2014
Posts: 854
There are probably countless drugs already available but may or may never be approved. Research chemicals are not regulated but untested. They're only approving junk like Fetzima extended release with a patent which was already approved in Europe for years..

It's all about how much money they can get from someone, most of these newer antidepressants don't work; the last 3 to hit the US market have failed pretty bad..

Fluoxetine 20mg 2009-2011, (Paroxetine 20mg 2012-2014) Effexor XR short time. Viibryd 2014-2015, Back on Paxil CR 25mg, Jan-July 2015.

Suboxone 2mg Effexor XR 150mg early 2016. Now 2016-2017: Paxil 20mg, Ativan, Lyrica, Adderall, Ambien CR.
SSRIManiac is offline  
post #13 of 34 (permalink) Old 09-19-2015, 03:06 PM
Permanently Banned
 
Join Date: Nov 2003
Location: Milwaukee, WI (BDSM sadist, Libertarian)
Gender: Male
Age: 47
Posts: 38,433
Quote:
Originally Posted by Caedmon View Post
Only two things I know of that sound promising are:

- ketamine
https://en.wikipedia.org/wiki/Ketamine#Depression

- opioid agonist/modulator thingy ALKS 5461
http://www.medscape.com/viewarticle/805197

"Everything old is new again"
"New" -- Ketamine was created in 1962 and opioids were used for depression prior to the 1950s when MAOIs & TCAs were created. "New" means older than me!
UltraShy is offline  
post #14 of 34 (permalink) Old 09-22-2015, 01:20 AM
baclofen enthusiast
 
swim's Avatar
 
Join Date: Apr 2011
Location: Italy
Gender: Male
Age: 44
Posts: 2,748
Tedatioxetine from Lundbeck, the triple reuptake inhibitor.
https://en.wikipedia.org/wiki/Tedatioxetine

Dx: depression, GAD, narcissistic personality disorder
Rx: Sereupin (paroxetine) 20mg, Remeron (mirtazapine) 15mg, Deniban (amisulpride) 50mg, EN (delorazapem) 1mg, Halcion (triazolam) 250mcg
Prn: Provigil (modafinil) 200mg, Lioresal (baclofen) 25mg, Samyr Sam-e 400mg tablets and ampoules, Rivotril (clonazepam) 2mg, lormetazepam 2mg
Bad Rx: fluvoxamine, asenapine, bupropion

swim is offline  
post #15 of 34 (permalink) Old 09-22-2015, 10:26 PM
Permanently Banned
 
Join Date: Nov 2003
Location: Milwaukee, WI (BDSM sadist, Libertarian)
Gender: Male
Age: 47
Posts: 38,433
Quote:
Originally Posted by swim View Post
Tedatioxetine from Lundbeck, the triple reuptake inhibitor.
https://en.wikipedia.org/wiki/Tedatioxetine
Does it comes with those nifty sexual side effects we've come to expect from all the crap the FDA approves?
UltraShy is offline  
post #16 of 34 (permalink) Old 09-22-2015, 10:49 PM
SAS Member
 
Join Date: Feb 2015
Posts: 304
Jaihoexotine

a Irreversible MAOI, with built in potent NRI action, eliminating the need for a restricted diet.
Abolishes depression in most patients :P
jaiho is offline  
post #17 of 34 (permalink) Old 09-23-2015, 06:51 AM Thread Starter
SAS Member
 
Join Date: Aug 2010
Location: California
Gender: Male
Age: 30
Posts: 851
Quote:
Originally Posted by jaiho View Post
Jaihoexotine

a Irreversible MAOI, with built in potent NRI action, eliminating the need for a restricted diet.
Abolishes depression in most patients :P
You have a link for information on it?
Iwillovercomeanxiety1 is offline  
post #18 of 34 (permalink) Old 09-23-2015, 04:33 PM
SAS Member
 
Join Date: Feb 2015
Posts: 304
Nope, cos i made it up. haha. I wish they made something like it though.

A promising anti depressant ive used is NSI-189
jaiho is offline  
post #19 of 34 (permalink) Old 09-23-2015, 04:57 PM
Permanently Banned
 
Join Date: Nov 2003
Location: Milwaukee, WI (BDSM sadist, Libertarian)
Gender: Male
Age: 47
Posts: 38,433
Quote:
Originally Posted by fotschi View Post
No way is ketamine going to be used. Too much abuse potential. I'd abuse the **** out of it myself if MXE wasn't cheaper.
So the rest of us should suffer and there should be 1 million suicides worldwide every year because you can't control yourself? Are you more important than everybody else? You're an adult and you're responsible for your own choices, be they good or bad. A significant number of suicides could be prevented -- the true measure of an antidepressant.
UltraShy is offline  
post #20 of 34 (permalink) Old 09-23-2015, 05:08 PM
Permanently Banned
 
Join Date: Nov 2003
Location: Milwaukee, WI (BDSM sadist, Libertarian)
Gender: Male
Age: 47
Posts: 38,433
Quote:
Originally Posted by DesperateGuy View Post
Unfortunately, the vast majority of "promising" treatments turn out not to work. The best stuff we currently have is decades-old.
Belsomra was supposed to be a wonderful new sleep aid, not targeting GABA as the vast bulk of sleep aids do.

On drugs.com you can look up patient reviews where it gets 3.4 (out of 10) with most folks saying "free was the right price because it doesn't work." I don't know of any drug with a lower rating.

You can get free samples of your own: in 10mg, 15mg, & 20mg -- you get 10 of each free, by simply going to www.Belsomra.com and printing out a certificate.

I told my GP how 180 mg failed to even make me tired. 30 mg failed to make my mother tired.

And this is the kind of crap the FDA approves -- a sleeping pill virtually guaranteed to not put you to sleep.
UltraShy is offline  
Reply

Thread Tools
Show Printable Version Show Printable Version
Email this Page Email this Page



Similar Threads
Thread Thread Starter Forum Replies Last Post
Any anti-anxiety medications without lactose or gelatin? candiedsky Medication 14 07-17-2018 11:31 AM
Mother and Fiance are against me getting on anti-anxiety medications??? ShrimpSauce Medication 6 01-19-2012 03:54 PM
Anti Anxiety Medications... Iwillovercomeanxiety1 Medication 5 09-12-2010 04:51 PM
poll of antidepressnts/anti anxiety medications metamorphosis Medication 0 02-15-2009 12:56 PM
Future Prospects on Antidepressants? seattleguy35 Medication 5 02-07-2006 03:13 PM

Posting Rules  
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are Off
Pingbacks are Off
Refbacks are Off

 
For the best viewing experience please update your browser to Google Chrome