I'm on Pristiq (desvenlafaxine), the new Effexor (I think, too lazy to open a new tab to check).
I just realised what an earlier poster said about missing your dose by as little as two hours... perhaps THAT'S why I've been getting headaches on this stuff!
It removes the "fear" of social situations for me. But it doesn't provide me the energy/enthusiasm to be engaging. I would still think something is needed to 'pep' me up to be more outgoing.
It does give me headaches and anxiety when I don't take it on time... most nights I remember, sometimes I forget (maybe once a week... tardy, I know). Also, sometimes I'll take it at 8PM, sometimes at midnight. I think this is not a good idea, since now it's only just clicked that this might be causing the headaches! Withdrawal is going to be a *****
Motivation is not too bad on Pristiq... mostly normal. Lexapro for me was bad for motivation/energy.
Sometimes I get mild anxiety on this stuff... something I've never had. It's almost like I stress over small things, things that don't even matter. And logically I know they don't matter... but the feeling of "OMGWTFSH!T" is there. This comes and goes from time to time. Maybe once every couple of days.
Sex drive is -2/10 though. I've posted elsewhere I feel like I have no penis anymore
Sex drive is extremely low, with fleeting surges of desire back to normal levels - but they're extremely short-lived.
What else? Hmm... drinking. I drink quite heavily on this stuff, and I'm mostly fine. Apparently one night I got super drunk and flopped my willy out on camera (embarassing)... another night I felt normal and had a nice warm shower, brushed my teeth and read a bit before going to sleep after a whole night of clubbing and heavy drinking. I can't really say how I am with alcohol because sometimes I'm fine, sometimes I'm not! Note this is only for heavy drinking... at normal levels (i.e. not binge-ing) you'll be fine.
That being said, I can definitely say I would prefer to be medication-free. Even with the slight benefit of reduced fear in social situations, there's nothing quite like that clearness you have with a drug-free lifestyle. I'm working towards that... unless a quick trial of Wellbutrin (as soon as I can convince my doctor to trial me on it) proves super highly motivating, without the anxiety issues some people complain about! :P Drug-free clearness might be great, but it will always come second to drug-induced wiredness with unflappable motivation