Augmentation of Exposure Therapy With D-Cycloserine for Social Anxiety Disorder - Social Anxiety Forum
 
Thread Tools
post #1 of 1 (permalink) Old 11-05-2008, 03:25 PM Thread Starter
taking a break from SAS
 
Join Date: Oct 2008
Gender: Male
Age: 35
Posts: 1,408

Augmentation of Exposure Therapy With D-Cycloserine for Social Anxiety Disorder


Stefan G. Hofmann, PhD; Alicia E. Meuret, PhD; Jasper A. J. Smits, PhD; Naomi M. Simon, MD, MSc; Mark H. Pollack, MD; Katherine Eisenmenger, MD; Michael Shiekh, MD; Michael W. Otto, PhD


Arch Gen Psychiatry. 2006;63:298-304.

Context Social anxiety disorder (SAD) is common and debilitating. Although exposure therapy is one of the most effective forms of psychotherapy for this disorder, many patients remain symptomatic. Fear reduction in exposure therapy is similar to extinction learning, and early clinical data with specific phobias suggest that the treatment effects of exposure therapy for SAD may be enhanced with D-cycloserine, an agonist at the glutamatergic N-methyl-D-aspartate receptor.

Objective To determine whether short-term treatment with 50 mg of D-cycloserine enhances the efficacy of exposure therapy for SAD.

Design Randomized, double-blind, placebo-controlled augmentation trial examining the combination of D-cycloserine or pill placebo with exposure therapy for SAD.

Setting Patients were self-referred from the general community to 1 of 3 research clinics.

Participants Twenty-seven participants meeting DSM-IV criteria for SAD with significant public speaking anxiety.

Interventions Following a diagnostic interview and pretreatment assessment, participants received 5 therapy sessions delivered in either an individual or group therapy format. The first session provided an introduction to the treatment model and was followed by 4 sessions emphasizing exposure to increasingly challenging public speech situations with videotaped feedback of performances. One hour prior to each session, participants received single doses of D-cycloserine or placebo.

Main Outcome Measures Symptoms were assessed by patient self-report and by clinicians blind to the randomization condition before treatment, after treatment, and 1 month after the last session.

Results Participants receiving D-cycloserine in addition to exposure therapy reported significantly less social anxiety compared with patients receiving exposure therapy plus placebo. Controlled effect sizes were in the medium to large range.

Conclusion The pilot data provide preliminary support for the use of short-term dosing of D-cycloserine as an adjunctive intervention to exposure therapy for SAD.


Author Affiliations: Department of Psychology and Center for Anxiety and Related Disorders, Boston University (Drs Hofmann, Meuret, Eisenmenger, and Otto) and Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital (Drs Simon, Pollack, and Otto), Boston; and Department of Psychology, Southern Methodist University, Dallas, Tex (Drs Smits and Shiekh).

http://archpsyc.ama-assn.org/cgi/con...tract/63/3/298
bowlingpins is offline  
Reply

Thread Tools
Show Printable Version Show Printable Version
Email this Page Email this Page



Similar Threads
Thread Thread Starter Forum Replies Last Post
taking on social anxiety (my exposure therapy) Chris1981 Triumphs Over Social Anxiety 3 08-06-2013 12:22 PM
Passive Agressive Disorder in Combination with Social Anxiety Disorder sean7phil Secondary Disorders 1 11-03-2011 01:41 PM
Social Anxiety Disorder/Avoidant Personality Disorder NinaAsha Coping With Social Anxiety 2 11-25-2008 11:52 PM
Social Anxiety Disorder or Social Phobia? Noca Voting Booth 13 06-13-2007 01:58 PM
Anxiety Disorder Medication Therapy? Hormones? ohiomom Medication 4 10-28-2006 06:59 AM

Posting Rules  
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are Off
Pingbacks are Off
Refbacks are Off

 
For the best viewing experience please update your browser to Google Chrome