I have been trying this for about 3 weeks now and the results are impressive. At first it made me kind of anxious when I took it. For the first two weeks I tried to take it once a day before an event where I had to speak to several people
The real turn seemed to be when I started taking it with B6 - then wow - my anxiety was reduced almost to nill. I had a great heightening of mood and lifting of depression as well. I have tried B6 alone before with not such a pronounced effect so it seems there is a synergistic effect.
I know that biologically cycloserine can reduce B6 absorption or bioavailability - I'm not sure the mechanism but I know when taken for TB it is common to take B6 with seromycin (cycloserine).
B6 is a cofactor in several enzymatic steps that result in producton of serotonin GABA and dopamine so alone I'm sure it has mood lifting qualitities - ones that may poop out some as the body gets used to higher doses of B6 due to upregulations - hopefully this wont be the case but in my experience with substrate therapy such as amino acids and vitamin/mineral cofactors often a tolerence is reached and time off is needed.
As stated earlier however, I have used B6 alone before with results nothing like I'm experiencing with both B6 and cycloserine.
I use 250 my capsules so my dose is usually inexact but I poor (bump) a small bit from the capsule into my mouth when I use it - probably resulting in about 25-75mg per use. I take this with 500 -1000mg B6.
Now of course with B6 I have to be wary of developing neuropathy over time with use of 2000mg or greater/day for prolonged period of time so I'm trying to stay under 2000/day and take a few days off. Also, if this regimen does indeed result not only in the immediate effects I'm seeing but long term re-learning and neuroplastic change in reduction of social fear I'm hoping not to have to use it for more than a month and maybe re-visit it from time to time. Ideally I would use this with CBT but my current circumstances do not allow me to be in therapy. I have been using daily affirmations for about 10 min to a half hour however after taking the cycloserine and may also try some hypnotherapy if I can find some good stuff online that I like.
My mood, sociability, confidence and working memory all seem to be greatly improved by this.
Will try to update at a later time.