Gut bacteria "consuming" GABA - Social Anxiety Forum
 
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post #1 of 14 (permalink) Old 07-11-2016, 10:21 AM Thread Starter
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Gut bacteria "consuming" GABA


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Bacteria have been discovered in our guts that depend on one of our brain chemicals for survival. These bacteria consume GABA, a molecule crucial for calming the brain, and the fact that they gobble it up could help explain why the gut microbiome seems to affect mood.

Philip Strandwitz and his colleagues at Northeastern University in Boston discovered that they could only grow a species of recently discovered gut bacteria, called KLE1738, if they provide it with GABA molecules. “Nothing made it grow, except GABA,” Strandwitz said while announcing his findings at the annual meeting of the American Society for Microbiology in Boston last month.

GABA acts by inhibiting signals from nerve cells, calming down the activity of the brain, so it’s surprising to learn that a gut bacterium needs it to grow and reproduce. Having abnormally low levels of GABA is linked to depression and mood disorders, and this finding adds to growing evidence that our gut bacteria may affect our brains.
Full article: https://www.newscientist.com/article...he-first-time/

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post #2 of 14 (permalink) Old 07-11-2016, 10:24 AM
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Those bacterias might be chillin'

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post #3 of 14 (permalink) Old 07-11-2016, 10:26 AM
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Thats why taking antibiotic makes me depressed... It kills the gut bacteria.
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post #4 of 14 (permalink) Old 07-11-2016, 10:31 AM
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Originally Posted by M0rbid View Post
Thats why taking antibiotic makes me depressed... It kills the gut bacteria.
I think it will be the other way around, the bacteria is the one responsible for the depressive mood since it feeds of GABA which regulates mood in a relaxative way.

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post #5 of 14 (permalink) Old 07-11-2016, 10:33 AM
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Thats why taking antibiotic makes me depressed... It kills the gut bacteria.
Eating fermented foods or taking probiotics helps replace the good bacteria that dies when you take antibiotics.

What's wrong with running away from reality if it sucks?

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post #6 of 14 (permalink) Old 07-11-2016, 10:44 AM
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Would it have anything to do with cortisol, the stress hormone?

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post #7 of 14 (permalink) Old 07-11-2016, 11:24 AM
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Very interesting article.

It's a constant battle between good bacteria and bad bacteria in the gut. Theoretically, if you supplement with good bacteria via pilla, it should be enough to tip the balance in the right direction. Also, reducing sugars that feed the bad bacteria helps. Not to mention an overall diet.

I saw a documentary recently about the gut bacteria. They said just before birth, the vagina fills with some of the bacteria the baby needs, so when the baby comes out it is filled from head to toe with these. Also, after that, breastfeeding transfers the baby 700 types of bacteria. Yes, 700, not a typo. Then there is the bacteria we gather from the environment, from coming in contact with soil, leaves, natural matter. They said that is was crucial that we do that, and not only in childhood, but through all our lives. Studies done showed that kids raised in cities, in apartments had way less beneficial gut bacteria cause they were living too clean, not being in direct touch with dirt, soil, trees, bugs, nature in general, literally getting dirty.
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post #8 of 14 (permalink) Old 07-11-2016, 12:08 PM Thread Starter
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I saw a documentary recently about the gut bacteria. They said just before birth, the vagina fills with some of the bacteria the baby needs, so when the baby comes out it is filled from head to toe with these.
That is why babies delivered via cesarean section are generally born with poor health. However, giving babies a swab of vaginal fluid after they've been born by c-section acts as a 'health boost'.

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Studies done showed that kids raised in cities, in apartments had way less beneficial gut bacteria cause they were living too clean, not being in direct touch with dirt, soil, trees, bugs, nature in general, literally getting dirty.
I guess that's why my grandfather always wanted us to "get involved" with nature like he used to. He's well reached his 90s now, with generally good health for his age.

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post #9 of 14 (permalink) Old 07-12-2016, 08:46 AM
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That is why babies delivered via cesarean section are generally born with poor health. However, giving babies a swab of vaginal fluid after they've been born by c-section acts as a 'health boost'.



I guess that's why my grandfather always wanted us to "get involved" with nature like he used to. He's well reached his 90s now, with generally good health for his age.
Did the grandfather knew about gut bacteria ? Why did he say to get involved ?

I myself was lucky to grow up in the countryside playing outside in dirt daily, then going eating tomatoes and cucumbers straight from the garden. We sometimes play in rain puddles, that was fun when I was in kindergarden.

We had no pc's back than or consoles and we had only 1 tv channel that had cartoons like once a week, so there was no reason to stay inside.
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post #10 of 14 (permalink) Old 07-12-2016, 08:55 AM
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Eating fermented foods or taking probiotics helps replace the good bacteria that dies when you take antibiotics.
How do you know it is good bacteria? What if humans aren't good?

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post #11 of 14 (permalink) Old 07-12-2016, 09:18 AM
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Fascinating article!

've read that the bacteria can communicate with the host's brain via neurons in the gut lining and the vagus nerve. So, like if the bacteria needs sweet stuff, it will electro-chemically communicate with the brain to give the host a craving for sweets. I've also read that the mitochondria within each of our cells originated as a separate bacterial organism and that viruses can incorporate pieces of RNA into the host's DNA.

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post #12 of 14 (permalink) Old 07-14-2016, 05:24 PM
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This is cool. I've always been interested in gut bacteria. It's essentially a second brain. IIRC, autism and gut bacteria are linked as well. It's no surprise gut bacteria has such an effect on mental states and processes and I wonder if fecal transplants (basically implanting the bacteria of another person to introduce good bacteria to another) can also help with SAS. I know it helps with c-diff. I hate antibiotics because they wipe out good bacteria (at least the broad spectrum ones). There are so many natural alternatives that both kill bad bacteria and keep the good intact, not just in the colon but other places as well like the skin and with infections.
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post #13 of 14 (permalink) Old 07-14-2016, 07:06 PM
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Off to eat some dirt!

Yeah this makes sense as they found a part of the brain that is part of the immune system.

https://www.nih.gov/news-events/nih-...nervous-system
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post #14 of 14 (permalink) Old 07-15-2016, 01:09 PM
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Did the grandfather knew about gut bacteria ? Why did he say to get involved ?

I myself was lucky to grow up in the countryside playing outside in dirt daily, then going eating tomatoes and cucumbers straight from the garden. We sometimes play in rain puddles, that was fun when I was in kindergarden.

We had no pc's back than or consoles and we had only 1 tv channel that had cartoons like once a week, so there was no reason to stay inside.
Being exposed to numerous types of bacteria as a child actually strengthens the immune system. A study was done showing that families that use dishwashers which sterilize everything had their children often grow up with higher chances of autoimmune conditions like eczema, whereas children who are exposed to more bacteria build up stronger immune systems.

I was like that too, using my hands to eat everything and not being over hygenic when I was a child. My immune system is better than anyone's in my family's because I'm guessing, my exposure to so much bacteria as a child. I get sick once in a blue moon in now and it clear up within days.
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