Do days off make you feel disoriented?

I work a regular Monday-Friday job. But I took today off and it's made me really disoriented. I keep feeling like I'm supposed to be at work. Yesterday I work up and thought it was Monday and I had to get up for work, and then I realized it was actually Sunday and I was off Monday. And it doesn't help that I've been really worried about something that might change when I go back. Also when I go on vacations for more than a day or two I get really anxious the night before I have to go back. Since it's a big change after being off for several days.