Social Anxiety Forum

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-   Miscellaneous Anxiolytics (Antianxiety) (https://www.socialanxietysupport.com/forum/f146/)
-   -   D-Cycloserine (https://www.socialanxietysupport.com/forum/f146/d-cycloserine-84125/)

Helena_SAS 02-26-2010 01:55 PM

D-Cycloserine
 
Cycloserine is an antibiotic effective against tuberculosis. It is also being trialed for treatment of phobias as well as an adjuvant to conventional treatments for depression, obsessive-compulsive disorder and schizophrenia.

More Info:
http://en.wikipedia.org/wiki/Cycloserine

Helena_SAS 03-01-2010 11:14 AM

Student
 
(Copied over from old review system)

Posted by Dreamer'sHideaway
Social Anxiety Background
I have suffered from social anxiety (likely for all my life) mainly since I was 16. I have had a few therapists over the years for cognitive behavioural therapy and have worked on changing my thoughts. I still have a lot of physical 'fear response' symptoms that make socializing very difficult. I do hope D-Cycloserine proves effective for positive treatment of "unlearning" fears - especially in social situations.

Other Treatments
(Years ago I tried Effexor, Paxil and Wellbutrin all at different times. None worked for me, though I may have been too young at that time- my brain was still developing into its adult stage).

Treatment Experience
My mother and I have done a lot of reading on websites about D-Cycloserine. We heard through Boston University that there are trials going on there, and that D-Cycloserine is still in the testing stage. We've heard only good things so far, and since its been around for a long time already for its original purpose... the side effects aren't an issue because its already been used safely on many.

I live in Canada and can't make the travel arrangements for the trial in Boston but I hope D-Cycloserine is successful and available within the next couple of years.

wxolue 03-08-2011 09:19 PM

I completed this study at BU. They are testing D-Cycloserine for its efficacy in increasing people's response to therapy. As you said, it helps unlearn social behaviors and thoughts. The therapy during the study was working for me, but my success turned around for a number of unrelated issues. I do not know if I received the placebo or the actual D-Cycloserine, so I can't speak to it's effectiveness.

Drew 03-08-2011 10:04 PM

Quote:

Originally Posted by wxolue (Post 1058861501)
I completed this study at BU. They are testing D-Cycloserine for its efficacy in increasing people's response to therapy. As you said, it helps unlearn social behaviors and thoughts. The therapy during the study was working for me, but my success turned around for a number of unrelated issues. I do not know if I received the placebo or the actual D-Cycloserine, so I can't speak to it's effectiveness.

Do you know when the study is supposed to be released?

wxolue 03-09-2011 05:51 PM

I'll ask. May take a week or so. They're slow on the replies lol.

Drew 03-09-2011 05:53 PM

Thanks for asking. :)

wxolue 03-12-2012 03:58 PM

Finally found out I was not a control in the study I participated in. In other words, I went through a 12 week professional group CBT based anxiety program while taking D-Cycloserine. First and foremost, it should be noted that I have little to compare my experience with exposure therapy to, as I have never done any other exposure therapy programs. With that said, the exposure therapy, particularly the public speaking exposure, worked amazingly well. Although the exposures have not lasted until now (a year and a half later), I think there were some residual benefits, and while difficult to execute, the experience was positive on the whole.

I can't say how well exposure therapy would work for me otherwise, but with the drug I found that every week I improved greatly in my public speaking. It actually shocked me how quickly I was becoming comfortable with public speaking. Looking back, I should have expected that I was on D-Cycloserine.

mark555666 03-14-2012 09:20 AM

Cool man, what are the results of the study?

wxolue 03-14-2012 10:53 AM

they haven't published it yet

mark555666 03-14-2012 01:49 PM

CBT seems good anyway. It goes straight to the core of the problem.

wxolue 04-19-2012 01:26 AM

Found out I actually was taking it. When I think about it, the progress I made with public speaking was shockingly fast. I had this suspicion even before I found out I was taking it. Really have nothing to compare it to, as I've only ever done CBT with it, but I think this is a great drug.

socialpiranha 04-11-2013 03:14 PM

very little info in regards to personal experience with this drug a couple people over at dr bob back in the day and a couple here thats about it. I will be ordering it soon and for future interested parties will post and rate my experience.

beanbaby 07-03-2013 01:30 AM

I`m doing Dr. Richards audio tapes and am on week 2. i listen to the audio tapes every day, and do the excersises when i can.. if i take D clycoserin 50 mg with 1 hour before each session would it help? please note the therapy is almost 5 months long. can i continue taking it for that long?

beanbaby 07-04-2013 04:21 AM

bump!!

WhiteColor 12-17-2013 06:24 AM

I'll bump this. I'm thinking of buying some.

alex921 12-20-2013 04:53 PM

Where can you buy it?

mab464 12-21-2013 08:31 PM

Are Cycloserin and D-Cycloserin the same? In other words are they both expected to do the job?

illusoryman 03-05-2014 10:48 PM

Would also be interested in feedback from anyone who's tried this. A few other anecdotal reports on the Internet report interesting results. Also this study - http://www.ncbi.nlm.nih.gov/pubmed/16520435

Any idea how one would get access to this?

loneliness 03-08-2014 07:37 AM

This drug always fascinated me, but I imagine it's a very bad idea to take it without supervision because while it may enhance the learning of more adaptive ways of thinking, it only also amplify learning of negative ways of behaving and thinking.

illusoryman 03-08-2014 07:18 PM

Quote:

Originally Posted by loneliness (Post 1070982825)
This drug always fascinated me, but I imagine it's a very bad idea to take it without supervision because while it may enhance the learning of more adaptive ways of thinking, it only also amplify learning of negative ways of behaving and thinking.

I agree, but like with a lot of these non-mainstream treatments, if there's no program available, what are we to do? Hopefully not stick to poisonous SSRI's and short term fixes such as benzos. But yet that's pretty much all there is on offer in ways of mainstream treatment.


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