I found Pristiq to be quite helpful with anxiety when I started, and so it was suggested that I was upped to 100mg to get more of an effect, since my anxiety was better, but still high. When changing dose I had no difference at all, and so I was eventually told to tr switching meds, and one doctor told me to go up to 150mg, which I didn't prticularly want to do, I decided to wait until my regular doctor was back (she had been on leave) and she suggested that I try effexor. I'm currently taking half a 100mg tablet a day, which i was initially worried about since its a dose release tablet that you're not meant to break in half, but it hasn't been too bad, except for early withdrawl, feeling really down and anxious in the mornings. I've got a few more days of taking the half tablet before a day of nothing (not looking forward to that) and then I'll get started on effexor. Hoping that the withdrawl won't be too hellish.