I am on Pristiq and have been on it for the past 6 months. I started taking it during severe depression (which I've had on and off since I was a teenager). I'd never taken antidepressants before but this time I became desperate for a solution (a last resort for me). It has certainly helped me, along with ongoing consultations with a psychologist. In the first couple of weeks I had unpleasant side effects which I put up with, but it was well worth it. It has allowed me to focus my mind, and therefore benefit more from my psychological consultations. My mood has lifted and it allowed me to regain control of my life, and not feel 'severely depressed'. It is very important to get the correct dose though. When I did increase it too much, I had severe side effects, but I have been great since I reduced the dose to the correct amount to me. Being an anxious person as well, it has helped me to feel more confident.
Absolutely worth it for me. Some unpleasant side effects when going on Pristiq and changing dose are worth putting up with - the pain of being depressed is far worse. Worth considering if prescribed by your doctor