I've only been on one antidepressant, which is Lexapro. I've been using it for about six years. I feel it helps me a lot. The only negative side effect I've had, I think, is clenching my teeth, and that's only started pretty recently. My mom has also been on Lexapro for a long time, but she's been trying to go off it or at least lower her dosage since it causes her to grind her teeth.