I am on 60mg 1X daily for about 4 months and am feeling good. I have been on Cymbalta for 8 months now. I have been on Paxil several times in the past few years and that never worked out for me beyond the first 3-6 months.
Side affects for me are fairly minimal. Weight loss has been a bonus and I am not certain how much is related to my more healthy eating and exercise. Either way I am happy.
Randomly low libido, but not all the time, and some have occasional constipation.
All in all, the benefits versus side effects has been positive for me.