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epigenetic memory genetics gene editing dna
We know a great deal about how genetic traits are passed down from one generation to another. Itís simple enough to understand. Some characteristics, such as hair color or susceptibility to certain diseases, are handed down from parent to child and on and on. However, in recent years, scientists have learned that we donít only inherit our parentsí genetic information ó we can also inherit their epigenetic information through cellsí epigenetic memory.
Our epigenome influences which of our genes are expressed and to what extent. These modifications in an organismís DNA donít change the DNA sequence itself, and unlike our genome, which is coded into us from birth, our epigenome changes throughout our lifetime and can be influenced by such factors as the environment, lifestyle, age, and even disease state.
Previously, scientists assumed that changes in a personís epigenome due to these outside factors died with them, but recent research has shown thatís not the case. Epigenetic information can actually be passed down to offspring.
ďThe ability of mammals to pass on epigenetic information to their progeny provides clear evidence that inheritance is not restricted to DNA sequence and epigenetics plays a key role in producing viable offspring,Ē wrote biologists ZoŽ Migicovsky and Igor Kovalchuk in a 2011 study published in Frontiers in Genetics.
Researchers have been trying to better understand this epigenetic memory, and theyíve made remarkable progress on that front.
In 2014, scientists at the University of California, Santa Cruz, proved that one epigenetic mark could be passed down through generations, and in 2016, Tel Aviv University researchers claimed that they were close to figuring out the mechanisms that allow epigenetic inheritance to occur.
In April 2017, researchers from the European Molecular Biology Organization (EMBO) in Spain published a study in Science demonstrating how epigenetic memories of environmental changes can be passed down to 14 generations of glow worms.
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While the ability of the environment to affect the development of certain genes is remarkable in and of itself, even more remarkable is that we may be able to use this knowledge in our fight against certain genetically induced or genetically linked diseases.
Alzheimerís is thought to be caused by both genetic and environmental factors, and cancer could also have epigenetic causes. Neuropsychiatric, immunity, and mental retardation disorders are also viable areas of study for epigeneticists.
Understanding how the environment can affect the health of not just an individual but potentially their offspring as well could have a long-lasting impact on healthcare and disease prevention.
Weíre living at a time when techniques for genetic manipulation are better than ever before, thanks to next-generation sequencing methods and gene-editing techniques such as CRISPR-Cas9. Combined with this new knowledge of how certain epigenetic memories get passed down, we could possibly find ways to edit out any epigenetic factors that could negatively impact multiple generations.
Whether through genetic manipulation or some other form of treatment, our knowledge of how epigenetic memory works can change how we approach genetic diseases. At the very least, knowing that our environment and lifestyle can be inherited could lead some to make healthier decisions in this lifetime for the sake of future generations.
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