I had a terrible reaction to Lexapro. I also had a terrible reaction to Latuda and Nardil I think it was called. However, this doesn't mean it would not be effective with the next person. I was on Celexa for over 10 years, but not in the last 5 years or so. Celexa I had no problem with at all, but looking back, hard to tell if it had any real effect on me at all positive or negative. Celexa was HELL tapering off when I had to get off it. It took me over a year to taper off incredibly slowly, which shows how addictive it can be. There are people who simply cannot get off Celexa for life. Or other medications. It is either they are not tapering down slowly enough or they just don't have the willpower. People who taper down too fast often end up taking way higher to counteract it. If you are OK staying on any of these for life, then maybe that is a decision you can make. I am now on a very low dose of Zyprexa 3MG and nothing else.