I'm one of those who has had huge success with meds. It did take some trial and error though, and the first medication I tried wasn't the right one. I'm now on paxil and it has significantly helped my depression and anxiety. I actually have no noticeable side effects with this drug. Zoloft, on the other hand, gave me alarming side effects.
So there is a chance that medication could help. The difficult part is that everyone reacts differently. My therapist had me take this genetic test that would help us figure out which medications would work for me, so that's definitely something that could help if you decide to explore that route.
I wouldn't write them off completely. Just be ready to try more than one if you go for it.