Rhodiola and Curcumin Experience
- Rhodiola Rosea 250mg standardised root extract (2.5mg salidrozide, 7.5mg rosavins)
- Curcumin 500mg w/ Piperine 3mg (standardised curcuminoids 475mg)
- 2 x Rhodiola + 2 x Curcumin upon waking.
- 1 x Curcumin every 3 hours thereafter.
- Both supplements are reversible MAOIs (mild) with relatively short half lives.
- Reversibility negates need for MAOI diet.
- In theory should reduce breakdown of serotonin and noradrenaline, increasing the level of these neurotransmitters within the brain.
- Some studies suggest long-term increase in serotonin levels within brain can lead to an increase in the number of serotonin receptors themselves - improving signalling between cells.
- Week 1: little/no effect noticed on mood, anxiety level and mental wellbeing.
- Week 2: subtle effects noticed; slight improvement to mood and outlook.
- Week 3: improvement noticed; fewer negative thoughts, optimistic outlook, no longer get anxious adrenaline rush in heart, growing confidence and self esteem.
- Week 4: continued improvement in anti-anxiety and anti-depression effects noted in week 3. A feeling of the brain being "re-wired" in a positive way.
Also noted positive effect on sleep; reduced time to fall asleep, well rested upon waking.
- Went away for a weekend after week 3 and forgot to take supplements for 3 days. On day 3, noticeable brain fog / agitation / stress / cognitive impairment - very unproductive at work.
- These symptoms stopped within 24h after resuming dosing regiment.
- Mild twitch of the right eyelid intermittently when taking the supplements.
- Dry mouth / eyes noted particularly in morning and evening.
After trying about 20 different supplements for anxiety/depression, these two are the only with noticeable effects and improvement. The synergistic combination of these mild MAOIs appears to increase potency of inhibition overall. As noted above, it took about two weeks to feel effects. Overall, I'm very impressed with these supplements and will continue to use them in the long-term. The increase in neurotransmitters appear to take a while to work - perhaps as the brain "re-wires" and new pathways/receptors are created.