The daytime grogginess never went away for me over a prolonged period of taking 45mg/day.
As this blogger points out, two scales which are commonly used in depression research/drug trials count reduced appetite and sleeplessness as symptoms of depression, so mirtazapine by fixing these symptoms directly may give a falsely higher score of improvement.
So if today I decide to stop eating and sleeping and some other banalities, a week from now I'll be classified as a major depressive if I then took such a questionnaire
Great job there Hamilton!
I'm starting to see why everyone is depressed