Effexor (venlafaxine) [SNRI]

Description:
Effexor is the most commonly prescribed medication in the category of serotonin-norepinephrine reuptake inhibitors (SNRIs). It has been used in the treatment of major depression for many years and has recently been approved by the FDA for the treatment of Social Anxiety Disorder.

SNRIs are typically prescribed as a second option after SSRIs have not been effective or tolerated well. They function by affecting the amounts of serotonin, norepinephrine and dopamine in the body as well as their uptake in the brain. Effexor is reported to be effective among many SAD patients, though other patients do not find Effexor to be useful. Common side effects include insomnia and sexual dysfunction.

More Info: http://en.wikipedia.org/wiki/Effexor_xr

Askapatient.com Ratings:
http://www.askapatient.com/viewrating.asp?drug=20699

RevolutionHealth.com Ratings:
http://www.revolutionhealth.com/drugs-treatments/rating/effexor
14 Treatment Experiences:
The only med that has actually helped
Shared by SeaShell on Apr 29th, 2009
9 out of 13 people found this treatment experience helpful:
Social Anxiety Background
Social Anxiety disorder and GAD with bouts of severe Depression.
Other Treatments
Cilift (did nothing) Cipralex (did nothing) Xanor SR (did nothing) Stillnox Zopiclone Urbanol
Treatment Experience
My doc prescribed Effexor 75 when all other medication failed to have any effect on my anxiety and depression.

It took only 2 weeks for me to start feeling a difference. I'm sure most of you know what it's like to feel like **** everyday. That dead sinking feeling that never goes away. When no medication has helped you in any way...

Well gradually, I started feeling better. That sinking feeling started to lift and I felt more able to tackle my problems. My depression had caused my therapy to hit a brick wall, but with the depression easing, I was able to make a few breakthroughs.

I don't know I will ever be completely released from the icey grips of Anxiety Disorder or Depression, but Effexor has definitely helped take the edge off.
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Effexor/Venlafaxine XR 150mg
Shared by dss on Nov 3rd, 2008
29 out of 44 people found this treatment experience helpful:
Other Treatments
None before Effexor XR
Treatment Experience

I was on Effexor XR 150mg for about 2 years before recently stopping. I had tried to go up to 225mg but would wake up in the night with a very wierd/vivid state of mind and pulsing sounds in my head that would keep me up for 20 minutes. I went back to 150mg after that and stayed at that dose.

 Before Effexor XR I would label myself a shut-in. I would avoid social situations and any that I would force myself to go to I would feel terrible doing.

 After being on Effexor for a while I found I was slowly able to push myself to go out and do things that I previously would have avoided or dreaded doing. It helped me cope with the anxiety of being in the situations to some degree. After a couple years of being on it and avoiding a switch to other medication I decided to stop it and try some new meds. I do think Effexor was able to help me as a first step but I don't really feel like it's a very effective treatment for social anxiety. Perhaps for someone whos anxiety isn't too severe it could be an option but I think there are other options out there that don't have as many negatives as this.

 As for the side effects and the cons of the drug I will list what I had.

  • Constantly Tired , napping in the afternoon (no sleeping during the day since stopping)
  • Anorgasmia (Unable to orgasm , went away after some time but still felt wierd)
  • Zombie/Drugged feeling , always felt like I was sedated or drugged in a way
  • Night sweats
  • Waking with the wierd feeling mentioned at the top , would periodically happen even after being off of 225mg for a while.
  • Brain Zaps (Starting and Stopping the Medication)

After weening myself off Effexor and noticing just how different it makes you feel (side effect wise) I have a hard time reccomending it to anyone considering the amount of other options there are.
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eh...
Shared by kim00 on Dec 26th, 2008
23 out of 35 people found this treatment experience helpful:
Social Anxiety Background
I have soxial anxiety, panic disorder, and mild depression.
Treatment Experience
I was on a fairly low dose of this medication for around 2 months. I did notice a slight improvement in depressive thinking,and a small elevation of mood, which was nice, but I don't think this is an effective anxiety treatment.

I continued to have panic attacks throughout my treatment. They tended to be of a shorter than usual, but I noticed that whenever I was coming out of a panic attack, I'd get this sweeping nausea and a sudden headache. It was like the medication was working to stop the panic attack, but produced painful side-effects in the process. Eventually the nausea/headache feeling actually kept me from going out in public as much as the panic disorder did because I always felt like I was going to vomit.

I was completely unable to have orgasms on this medication. Also, I always felt full and had little apetite. I would go 2 days on nothing but a salad and a glass of water and not even notice.

I wanted to stay on the med just for the weight loss potential, but I actually GAINED weight because not being able to eat slows your metabolism to a crawl.

I had withdrawl symptoms when I stepped off this med.
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Mildly helped anxiety, helped a lot with depression
Shared by Drew on Dec 24th, 2008
20 out of 31 people found this treatment experience helpful:
Social Anxiety Background
Social anxiety has affected me since I was in elementary school. While it was triggered initially by a traumatic experience, it is something that runs in the family and I certainly had a predisposition for. Some examples of how it manifested itself over the years: avoiding certain types of social situations and friends, avoiding public speaking, avoiding the opposite sex completely, hiding in the library during lunch, the thought of just walking down certain hallways at my highschool terrified me, fear of being around large groups of people, fear and avoidance of going to parties or social gatherings, etc. My social anxiety started to get severe when I dropped out of college after one quarter because of my social anxiety. That's when I started to get uncomfortable just leaving my apartment and hit "the bottom" so to speak. Through treatment with group cognitive-behavioral therapy (CBT), Eye Movement Desensitization and Reprogramming (EMDR) for mild Post Traumatic Stress Disorder (PTSD), and medication I've been able to live the balanced life that I value and form healthy friendships and relationships.
Other Treatments
Prozac: Too activating. It amplified my anxiety.
Zoloft: It made me very apathetic and killed my libido even at a low dose that wasn't
Klonopin: Taken with Effexor, the two together have been the combination that has worked well for me.
Treatment Experience
After trying Prozac and Zoloft with no luck my psychiatrist prescribed me Effexor. It helped greatly the depression I was experiencing, but only mildly with anxiety symptoms. My feelings of hopelessness that I was having at the time went away and I had a lot of energy and motivation to do the things I needed to get done. This was a big change from Zoloft, which made me very apathetic.

I am at a relatively low dose, as I am very sensitive to medications, and have not experienced any of the more uncomfortable side effects others mentioned, even when I've missed doses. I have had mild anorgasmia and constipation, though. Lowering the dose a little bit got rid of these symptoms.

I've found taking Effexor in combination with Klonopin works great for both my symptoms of depression and anxiety.

As with all medications, your experience will be based on your biology. Everyone reacts to medications differently.
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Awesome!
Shared by Opie on Dec 27th, 2008
20 out of 33 people found this treatment experience helpful:
Social Anxiety Background
I've been very shy since I can remember.
Treatment Experience
I just recently came off Effexor. I was taking 225mg at night. I did not have any withdrawal symptoms coming off it. I was on it for about a year and a half. And it worked tremendously. It crushed my anxiety. Situations where I would get the fight or flight feeling, the adrenaline rush. Those feelings and thoughts were gone. Literally a miracle. The drug won't help unless you go out there and conquer your fears.
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Fairly helpful
Shared by redlegion on Oct 21st, 2008
18 out of 37 people found this treatment experience helpful:
Social Anxiety Background
I have a general social anxiety, but with a specific attention focused on authority figures. This probably stems from conflicts in the past with the USSS.
Other Treatments
I've been put on Welbutrin, Xanax, Paxil, Cymbalta, and a handful of others.
Treatment Experience

I've been on Effexor XR 150mg capsules for about a year and some change, now. So far, it's the only medication I've taken that actually prevents my symptoms from flaring up in the first place. To me, it's more important to prevent the symptom from appearing, rather than just zap it away as soon as the flare-up gets out of hand.

 While it's worked rather well and allows me to be personable and deal with customer service situations at work, I still have serious issues with figures of authority in particular.

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Nothing
Shared by livingnsilence on Oct 20th, 2008
14 out of 29 people found this treatment experience helpful:
Social Anxiety Background
Social anxiety runs in my family, and I don't respond to exposure or therapy, so it's probably genetic.
Other Treatments

Clonazapam

Treatment Experience

I was on 100mg of venlafaxine for a month. It had no affect on me what so ever. Because it is expensive without insurance I quit with very little tapering but the withdrawl wasn't bad. The only withdrawl symptom I had was some weird sensations in my head, neck and arms that pulsated, I guess it was the "shock" people describe but it didn't feel like a shock to me. The sensation  was bad except that it made it harder to fall asleep.

I will add, though, that I tend to have a high resistance to many different meds and usually need a much higher dose than normal to work.

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Useless for me
Shared by Skaz on Mar 4th, 2009
6 out of 13 people found this treatment experience helpful:
Social Anxiety Background
First anxiety shock at age of 11 - 12 years old, psych didn't realize it though. Officially diagnosed at age of 19. That was 8 years ago. Have been seeking treatment ever since. Tried a lot of medications and been through group CBT. My SA is a moderate - high type of the generalized variety. And it's getting worse in some areas while others seem to be getting better. Overall though it feels as it's becoming more of a problem as I get older.
Other Treatments
Paxil(seroxat), Cipramil, Xanax, Klonopin, Zoloft, Imovane and CBT. Paxil was hell compared to this, Cipramil and Zoloft actually rather similar with no concrete benefits. So far only Xanax, Klonopin and Imovane have helped to any degree and Xanax is the clear winner but has the unfortunate side effects of simply knocking me out a few hours after it peaks. Klonopin is more subtle and less effective and Imovone simply helps me falling asleep and thus avoiding periods of non helpful revisions and reflections of social situations. CBT isn't comparable as such but it was immensely helpful.
Treatment Experience
Me:
Overweight male of 26 going on 27 years, have been proven to be rather treatment resistant to pharmacological treatments, the jury is still out on the CBT one.

Ok, So I was started on this drug around 18 months ago. I started on 75 mg and went a month later to 150 mg. That continued for 2 months. And as I wasn't getting anything other than vague benefits at most I was increased to 300 mg in dosage. That hasn't increased the benefits to any remarkable or noticeable degree. So I started taking 450 mg, and have been doing that for around 10 months. This still hasn't had any concrete effects. All improvements I've had with my condition can also be attributed to other causes than the medication so it's at best vague if it's actually doing anything for me. So this is the last month I'm going to be on this drug.

Common side effects for me have been excessive sweating (after starting the 300 mg this kicked into high gear). And recently some involuntary muscle spasms as I'm falling asleep or relaxing have been becoming frequent. Other probable effects are constipation, headaches and so on...

Overall I don't think this drug is of any use for me even as an anti-depressant. And it's most certainly useless as an anti-anxiety med for me. So try it if you want to but based on myself it's not a guaranteed to be a useful treatment or even a helpful one.

Overall I can't recommend this medication as a possible treatment.
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the blues
Shared by shiftleft on Nov 1st, 2008
13 out of 29 people found this treatment experience helpful:
Treatment Experience

After the passing of a couple of family members I found myself with the blues.  The doc gave me Effexor 150 x2 per day which has been effective.  It took about 3 months to work and I just about took it back.  I felt even worse a couple of times, but since then it has stabilised my mood.  I have had a couple of times when i have been out of town and forgotten my meds - totally don't recommend missing them out, fuzzy head. 

 

Would recommend though

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no not really
Shared by stealyourface722 on Jan 2nd, 2009
8 out of 18 people found this treatment experience helpful:
Treatment Experience
Rasied my blood pressure, mood swings, increased appetite and cuased a bit of panic so it didnt really help with social anxiety
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Recommended Book

The Shyness and Social Anxiety Workbook: Proven, Step-by-Step Techniques for Overcoming Your Fear

Purchase book at Amazon

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The individual experiences about treatment for social anxiety disorder (social phobia) are not a substitute for medical advice.

You should always consult a qualified health care professional before beginning, changing or stopping a treatment.

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