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Hi I was on Lexapro for about 7 years combined with different other meds for depression/anxiety. Last summer the combo just didn't seem to work anymore so my pdoc tried me on Prozac instead. I didn't do well on it, my depression got worse and I was always hungry Eventually I ended up on Effexor and Wellbutrin. The combination has been very effective for me. My pdoc keeps telling me that the day isn't too far away when they'll be able to just take blood and tell which medications to prescribe, but until then we're stuck with all of this trial and error which can be so frustrating and discouraging. I hope Prozac works for you, I know it's very effective for a lot of people, I just wasn't one of them. ~ Breanna