Why antipsychotics are a bad idea if you don't have psychosis

[Dr House]

Originally Posted by crayzyMed

There will be study's showing the incidine with seroquel i will find them and post them, i know seroqual has a lower incidence then others.

Its not that rare in general atypicals have a incidence of 4%, i just post the science and i wont make any new threads, just tought a general thread was a good idea about the dangers as ppl will need to be aware of them, i dont mind a thread of amp's dangers either.

win win and win again

[newboki]

Originally Posted by crayzyMed

There will be study's showing the incidine with seroquel i will find them and post them, i know seroqual has a lower incidence then others.

Its not that rare in general atypicals have a incidence of 4%, i just post the science and i wont make any new threads, just tought a general thread was a good idea about the dangers as ppl will need to be aware of them, i dont mind a thread of amp's dangers either.

Well that 4 % is just statistic if we did stats on every single person it would be different so i don't look at statistics as something true. I take seroquel for almost 5 years now and nothing. Those statistic must be studied over two years period i assume not 20 years because seroquel doesn't exist 20 years.

PS Crazymed we are good now no more arguments between us, WE ARE FRIENDS, And if they ban me maybe it is for good, i wouldn't be visiting these forums and wouldn't worry about meds as much.

[crayzyMed]

WE ARE FRIENDS

Haha sure dude, i never got mad for your post, just posted a funny comment on them.

[crayzyMed]

Originally Posted by yelda

I dont agree with the idea that antipsychotics are only for psychotic people.
schizophrenics need high doses of antipsychotics but low doses of antipsychotics are for everyone.
I am not psychotic but low doses of antipsychoitcs are wonder drugs for me for anger management.
I think crazymed should be banned from the forum.

[Arisa1536]

Originally Posted by crayzyMed

AWWW
The carebare is WIN

Seroquel is BAD :/
You must be the size of a house no offense newboki, if u are still on it five years down the track, thats all it is really, weight gain in a pill

[Duke of Prunes]

Classy...

[jim_morrison]

Originally Posted by crayzyMed

There will be study's showing the incidence with seroquel i will find them and post them, i know seroqual has a lower incidence then others.

Yeah that's possible, according to the prescribing literature;

In pre-clinical tests predictive of EPS, quetiapine is unlike typical antipsychotics and has an atypical profile. Quetiapine does not produce dopamine D2 receptor supersensitivity after chronic administration. Quetiapine produces only weak catalepsy at effective dopamine D2 receptor blocking doses. Quetiapine demonstrates selectivity for the limbic system by producing depolarisation blockade of the mesolimbic but not the nigrostriatal dopamine-containing neurones following chronic administration. Quetiapine exhibits minimal dystonic liability in haloperidol-sensitised or drug-naive Cebus monkeys after acute and chronic administration.

Serial PET scans evaluating the D2 receptor occupancy of quetiapine have demonstrated that quetiapine very rapidly disassociates from the D2 receptor, so this may be an underlying mechanism as to why the incidence is low for this particular agent.

As with most atypicals, affinity for 5-HT2A > D2 is thought to play a role, however this study suggests that rapid dissociation alone may be a major indicator of atypicality.

http://ajp.psychiatryonline.org/cgi/...ract/158/3/360

RESULTS: Neuroimaging data show that optimal dopamine D2 occupancy is sufficient to produce the atypical antipsychotic effect. Freedom from motor side effects results from low D2 occupancy, not from high 5-HT2 occupancy. If D2 occupancy is excessive, atypicality is lost even in the presence of high 5-HT2 occupancy. Animal data show that a rapid dissociation from the D2 receptor at a molecular level produces the atypical antipsychotic effect. In vitro data show that the single most powerful predictor of atypicality for the current generation of atypical antipsychotics is fast dissociation from the D2 receptor, not its high affinity at 5-HT2, D4, or another receptor. CONCLUSIONS: The authors propose that fast dissociation from the D2 receptor makes an antipsychotic more accommodating of physiological dopamine transmission, permitting an antipsychotic effect without motor side effects, prolactin elevation, or secondary negative symptoms. In contrast to the multireceptor hypotheses, the authors predict that the atypical antipsychotic effect can be produced by appropriate modulation of the D2 receptor alone; the blockade of other receptors is neither necessary nor sufficient.

*If* lower incidence rates are associated with seroquel then this may be one possible explanation.

[Escopeta]

Is the average person supposed to understand all that?

[Duke of Prunes]

If somebody is going to take something, they should at least try to understand it.

[Escopeta]

Understanding something is one thing, breaking it down on a molecular level, so to speak, is a completely different thing. It isn't realistic to expect the average individual to come in this thread "Oh herp derp, I get it, durr". To me it just seems kind of pompus to spill a bucket load of block quotes of this information in staggering detail without at least breaking it down it layman's terms for stupid old me and the next guy to understand. Whatever, carry on.

[crayzyMed]

I will add a easy to undersand explanation one of the days.

[wjc75225]

I'm on 2mg of Abilify. I haven't noticed anything unusual, yet. I didn't read all of your data, but I will come back to it. Seroquel did not agree with me. I just felt "off" on it.

[BreakingtheGirl]

**

[Arisa1536]

Originally Posted by irishK

My dr tried me on Seroquel for my sleep disorder. It was a nightmare. I felt like I was in a coma but my mind was wide awake and racing. I couldn't move my body at all and I remember trying to will myself to even move my toes and nothing happened, and feeling suffocated under a massive weight. It was horrifying. I was pretty sure I was dying lol.

I eventually passed out and even the next day I could barely sit up. I had tried the lowest dose possible and had even fractioned it up, just knowing how sensitive I am to some meds. I'm now on Zopiclone which I'm going be tapering off of starting tonight. I still have Seroquel but won't ever use it again. It's been really tempting when I haven't slept for a couple of days, but the fear of going through that again isn't worth it personally. Just my experience.

I feel your pain
Seroquel made me a living zombie and adding it to people withdrawing from SNRI/SSRI antidepressants is NOT a good idea

Its Day four of my effexor withdrawals and the seroquel made me want to throw up
the withdrawals got so bad this morning that i took the seroquel out of the bin and thought "should I?" and i took one Big mistake
i feel even sicker than before, and the appetite has gone completely which is rather strange as the one thing seroquel were notorious for was creating insane hunger but the withdrawals are so bad that seroquel is not able to sedate me enough to eat, and all i did was drift in and out of a nightmare until waking up and coming online just now. Never again

[SilentWitness]

This thread is a real eye opener. I've been taking zyprexa and do not suffer from psychosis. I have been using it occasionally (once a week) as a sleep aid and helping ease social anxiety. It seemed like a miracle drug but I don't like the idea of these side effects

[Kon]

In the psychiatric hospital I worked at we used to call atypicals meds as "diabetes in a bottle". Not far off from being the truth.

[Medline]

@D11: Once per week for some time won't get you in trouble.

[crayzyMed]

Originally Posted by Medline

@D11: Once per week for some time won't get you in trouble.

Thats true.

[wjc75225]

Originally Posted by irishK

My dr tried me on Seroquel for my sleep disorder. It was a nightmare. I felt like I was in a coma but my mind was wide awake and racing. I couldn't move my body at all and I remember trying to will myself to even move my toes and nothing happened, and feeling suffocated under a massive weight. It was horrifying. I was pretty sure I was dying lol.

Seroquel was a nightmare for me, too. Abilify (at least at a low dose, which I'm on) seems to be ok, and maybe a little energizing.

[beaches09]

Would you say Lithium fits under some of those long term risks?