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Old 03-18-2010, 01:24 AM   #1 (permalink)
 
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Default Whats the relationship between serotonin dopamin and norepinephrin?

Is there any straightforward relationship between the three? Like, if one goes up the other goes down?
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Old 03-18-2010, 04:48 PM   #2 (permalink)
 
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If serotonin goes up, noradrenaline and dopamine levels decrease because certain receptors such as 5HT-2C inhibit the release of them. Antidepressants like agomelatine block the 5HT-2C receptor thus increasing the concentration of dopamine and noradrenaline and are termed "noradrenaline-dopamine disinhibitors", selective serotonin reuptake enhancers also disinhibit the release of dopamine and noradrenaline by reducing the amount of serotonin in the brain. It is believed to be the inhibition of dopamine release that is responsible for the negative sexual and mood blunting effects of ssri's.
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Old 03-18-2010, 05:06 PM   #3 (permalink)
 
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Quote:
Originally Posted by Ash09 View Post
If serotonin goes up, noradrenaline and dopamine levels decrease because certain receptors such as 5HT-2C inhibit the release of them. Antidepressants like agomelatine block the 5HT-2C receptor thus increasing the concentration of dopamine and noradrenaline and are termed "noradrenaline-dopamine disinhibitors", selective serotonin reuptake enhancers also disinhibit the release of dopamine and noradrenaline by reducing the amount of serotonin in the brain. It is believed to be the inhibition of dopamine release that is responsible for the negative sexual and mood blunting effects of ssri's.
I ve also read the opposite. That the reason why SSRIs work after a few weeks is because they are only able to increase dopamine after a few weeks. Or something along these lines.
Thats why I am a bit confused.

Edit: Found one source:

Quote:
Recent studies, including a 2005 article by Fu-Ming Zhou and colleagues, indicate that SSRIs do not act solely on serotonin; they also act on dopamine. SSRIs seem to "trick" dopamine transporters into producing serotonin signals, resulting in higher levels of both neurotransmitters.
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Old 03-19-2010, 12:05 AM   #4 (permalink)
 
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There does seem to be some relationship - For example SSRI's are thought to lower overall quantity's of noradrenaline and dopamine. At the same time there's the theory that the noradrenergic alpha-2 adrenergic receptor inhibits the release of noradrenaline and serotonin. And as someone's already mentioned, the theory that certain serotonin receptors (notably 5HT2C) inhbit the release of dopamine and noradrenaline.
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Old 03-19-2010, 03:12 AM   #5 (permalink)
 
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5HT1A also causes dopamine release among other things.
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