This may explain in part why I felt nothing when taking Picamilon, but for Klonopin I did.
Perhaps there's already 'enough' GABA in my brain; meaning, it's already saturated. It only needs to be activated.
Knowing what I knew about Picamilon at the time - GABA bonded to niacin for easy cross-over into the BBB - I had expected it to work, only to find out that it didn't. And that's assuming that it is
getting into the blood and not being quickly absorbed in the stomach. Without actually analyzing the blood, it would be hard to say.
And since the GABA just needed to be activated, which is what benzos primarily do, then that would explain why it worked extremely well in the beginning.
Looking at my still-unused Picamilon bottles, the average dose is 100mg. I've taken a few times that amount at a time without feeling anything, even though I've anticipated it. So if the GABA is already saturated, then taking a standard dosage, or many times the standard dosage, would both result in little to no feeling.
The question then becomes, for those oversatured people, how to activate it properly. With extreme resistence to Klonopin now, even though it still works better to anything else I've tried, including Xanax and Ativan, then how might the naturally-existing GABA get bound or activated again.
I guess that's easier said than done. The mechanism by which benzos work has already been adapted to by the brain - for the most part, anyway - and so only a different mechanism will do. The same with Phenibut - different mechanism, resulting in working for a time, and then nothing. The general consensus is that benzos work short-term for a majority of people, while MAOIs work long-term for a majority of people. As much as I didn't want to go the MAOI route, due to cost and possible long-term side-effects, it seemed to be the next-best thing, and with any luck, will work better than benzos do.
I don't think I'll be holding my breath though, even when, or if, I do receive it. Spending many hours reading post after post on Dr. Bob and anxietyhelp.org for the preparation of it is exhausting enough.