Originally Posted by Dpbthgt
Can you go into more detail on how and why this works? Also, is it fluoxetine specific? If so why? Thank you.
I'm interested in the positive aspects of it but it sounds risky.
I've got a kind addicted to snorting bupropion. It induces short rush and then some controllable slightly hypomanic state. Energy, motivation, talkativeness, hypersexuality and a touch of euphoria. I snort it to bypass first-pass liver metabolism so let more of bupropion itself (which is mostly dopaminergic) reach the brain (before it is converted to hydroxybupropion, see here
their affinities for monoamine transporters and compare). And I take fluoxetine, which inhibits enzyme converting bupropion into mostly noradrenergic and much more long-living hydroxybupropion (which is responsible for often observed anxiogenic effect).
Fluoxetine is not specific and i suspect not the most efficient. "Since bupropion is metabolized to hydroxybupropion by the CYP2B6 enzyme, drug interactions with CYP2B6 inhibitors are possible: this includes medications like paroxetine, sertraline, norfluoxetine (the active metabolite of fluoxetine), diazepam, clopidogrel, and orphenadrine. The expected result is the increase of bupropion and decrease of hydroxybupropion blood concentration".
At the same time, fluoxetine is known
to greatly potentiate DA/NE raise with bupropion. They speculate this is due 5HT/DA systems interaction, but I'd consider that metabolic effect + 5HT2C receptors antagonism by fluoxetine which has its own