the best medication for social anxiety

[jakeforpresident]

Hey all,

I think we should come up with a top 5 list for meds when it comes to treating social anxiety.

Here are the options:

• benzodiazepines
• SSRI's
• SNRI's
• Dopaminergic agents
• MAOI's
• atypical antipsychotics (for comorbid bipolar)
• Buspar
• Remeron
• TCA's
• etc.

basically i want to try a new drug and am wondering if anybody has had long term success with any particular ones.

[crayzyMed]

My list of things i consider usefull for social anxiety (not by personal experiences, but by many succesfull anecdotal reports).

- Stimulants (like dexedrine or adderall)
- Opiates (like oxycodone)
- GHB (Probebly impossible to get unless you got a really good doc).
- MAOI's
- Agomelatine
- NMDA antagonists (like memantine)
- High dose tandospirone
- Low dose Amisulpiride
- Benzo's
- Lyrica

Those are 5 meds i consider most effective:

- Stimulants
- Opiates
- GHB
- Benzo's
- MAOI's

I left out MDAI as its not aproved as a medication.

[rocknroll714]

Originally Posted by crayzyMed

My list of things i consider usefull for social anxiety (not by personal experiences, but by many succesfull anecdotal reports).

- Stimulants (like dexedrine or adderall)
- Opiates (like oxycodone)
- GHB (Probebly impossible to get unless you got a really good doc).
- MAOI's
- Agomelatine
- NMDA antagonists (like memantine)
- High dose tandospirone
- Low dose Amisulpiride
- Benzo's
- Lyrica

Those are 5 meds i consider most effective:

- Stimulants
- Opiates
- GHB
- NMDA antagonists
- MAOI's

I left out MDAI as its not aproved as a medication.

NMDA antagonists? Huh??

Everything else I agree with.

My list:

- Entactogens (MDA, MDMA ("Ecstasy"), MDEA, MBDB, MDAI, etc)
- Stimulants (Amphetamine, Methamphetamine, Amineptine, Desoxypipradrol, etc)
- Opioids (Codeine, Hydrocodone, Oxycodone, Morphine, Heroin, Tramadol, etc)
- Depressants (GHB, Alcohol, Barbiturates, Benzodiazepines, Pregabalin, etc)
- MAOIs (Nardil, Parnate, Marplan, etc)
- TCAs (Anafranil, Tofranil, Elavil, etc)
- Other ADs (Agomelatine, Tianeptine, Tandospirone, Opipramol, etc)

[crayzyMed]

Originally Posted by rocknroll714

NMDA antagonists? Huh??

Everything else I agree with.

- Entactogens (MDA, MDMA, MDEA, MBDB, MDAI, etc)
- Stimulants (Amphetamine, Methamphetamine, Amineptine, Desoxypipradrol, etc)
- Opioids (Codeine, Hydrocodone, Oxycodone, Morphine, Heroin, Tramadol, etc)
- Depressants (GHB, Alcohol, Barbiturates, Benzodiazepines, Pregabalin, etc)
- MAOIs (Nardil, Parnate, Marplan, etc)
- TCAs (Anafranil, Tofranil, Elavil, etc)
- Other ADs (Agomelatine, Tianeptine, Tandospirone, Opipramol, etc)

Some ppl only seem to respond to NMDA antagonists, cant explain it. But putting it in the top 5 was a bit too fast, benzo's should deserve that place.

[jakeforpresident]

Originally Posted by crayzyMed

Those are 5 meds i consider most effective:

- Stimulants
- Opiates
- GHB
- NMDA antagonists
- MAOI's

I left out MDAI as its not aproved as a medication.

What is MDAI and can you buy it??

[Freesix88]

Klonopin pretty much cured me. I don't care what people think of me anymore.
I still lack that drive to communicate with other people though. Ritalin, for example. works for this. Powerful stimulants are the best for depression. (desoxypipadrol hell yeah way too strong btw)
Stay away from anti depressants they do not really work. I've read so many replies on this forum and almost nobody seems to benefit from them.

I would still like to like to try GHB someday anyway, just for fun :P.

[crayzyMed]

Originally Posted by jakeforpresident

What is MDAI and can you buy it??

Read my own thread for more info about it. Its a SSRA (Selective serotonin releasing agent). It however is only available as an Research chemical so trialling this substance is experimental.

[rocknroll714]

Originally Posted by crayzyMed

Some ppl only seem to respond to NMDA antagonists, cant explain it.

Ohh you meant like ketamine for treatment-resistant depression. That totally went over my head lol. Yeah ketamine and [possibly] other NMDA antagonists as well.

Originally Posted by jakeforpresident

What is MDAI and can you buy it??

MDAI is an MDMA homologue (sort of -- they're related structurally, albeit rather distantly). It's different than MDMA in that MDMA is a triple releaser of serotonin, norepinephrine, and dopamine, while MDAI is selective only for serotonin. MDAI is superior to MDMA in some senses in that it doesn't produce neurotoxicity, isn't addictive, and is fully legal, but at the same time it's far less effective for depression and anxiety than MDMA itself. Nonetheless, it's still a fabulous drug and it can kind of be thought of as what SSRIs should have been. You can order MDAI online relatively inexpensively.

[crayzyMed]

Originally Posted by rocknroll714

Ohh you meant like ketamine for treatment-resistant depression. That totally went over my head lol. Yeah ketamine and [possibly] other NMDA antagonists as well.



MDAI is an MDMA homologue (sort of -- they're related structurally, albeit rather distantly). It's different than MDMA in that MDMA is a triple releaser of serotonin, norepinephrine, and dopamine, while MDAI is selective only for serotonin. MDAI is superior to MDMA in some senses in that it doesn't produce neurotoxicity, isn't addictive, and is fully legal, but at the same time it's far less effective for depression and anxiety than MDMA itself. Nonetheless, it's still a fabulous drug and it can kind of be thought of as what SSRIs should have been. You can order MDAI online relatively inexpensively.

Yeah NMDA antagonists are for many ppl very effective, but as this thread was about social anxiety only i've replaced them with benzo's in my top 5. Altough there are some ppl that only seem to respond to them for social anxiety aswell, so they also deserve some credit here.

Edit: Besides i recommend against trying MDAI at this point as barely any ppl tried taking it on a regular basis, its very experimental, there are many treatments available that are known to be safe and effective.

[crayzyMed]

Originally Posted by rubyruby

to anyone:
When you say you take stimulants - do you take them alone or are you taking them with an antidepressent. Usually people with SA are nervous so I have a hard time understanding how a stimulant would be helpful.

The only thing I have heard of is strattera (used for ADD/depression).

Just wondering what the logic is behind using a stimulant.

In my case amphetamines cure me of social anxiety, while benzo's dont do a thing, its a matter of pharmacology not a matter of it making you more nervous. For some ppl its just the opposite.

[Vini Vidi Vici]

all these lists i completely agree with....stimulants are the most effective drugs in existence for my SA. Amphetamine, nicotine, Caffeine, Ritalin,.....i think they help because they give me a desire to socialize with people....however, with repeated use, anxiety starts becoming more prevalent, so a GABAergic compound is necessary at the same time as the Stimulant. Benzos, by themselves, are not very helpful for me. They certainly take away alot of the tension and worry and phsyical symptoms of SA, but i still have Zero motivation to communicate with others, which i believe is a considerable cause for my anxiety. The combination of Benzo/Alcohol/other GABAergic + Stimulant has always been the most effective for me.

here is my list, which is nearly the same as the others:

Dopaminergic Stimulants-- (amphetamine--used short-term, for like 3-7 days it helps, after that, the beneficial effects completely reverse)
Opiates
5ht2c (selective) antagonists (Agomelatine)
GABAergics--Klonopin, Valerian, Kava Kava
DXM/NMDA antagonists (??? i have no clue as to exactly which mechanism of DXM helps me, but DXM + Adderall + nicotine was great for me)
Nicotine

i despise all SSRIs and SNRIs. I thought MAOIs would be different , because they work for so many people. One could almost say that an MAOI would work for anyone, if they could tolerate the side effects...however, I personally hate Parnate. I feel no emotion, no drive to do anything, and i can't enjoy anything. I can say in complete truth that i felt better taking Tramadol + Xanax. On Parnate, my anxiety/worry is greatly reduced. However, i just don't care. I have no motivation to talk to anyone. So even in the presence of people, i still suffer considerably, because i cannot think of anything to say, because i feel nothing. I have no emotions anymore, just as i had no emotions on SSRIs.... SA is reduced. but there is no point...either way, i don't talk to anyone. .......the only option i can think of would be to add Mianserin or Mirtazapine to counteract the negative/undesirable Serotonergic effects of Parnate....but still.

[Vini Vidi Vici]

sorry about my rambling last post...i doubt it was relevant to the topic. most people actually do Great on MAOIs.

but soon, i hope to change my medication regimen to the following:

Dextroamphetamine 10mg 3x/day, Tramadol 50mg 3x/day(or other Opiate), Memantine 5-20mg once every 2-4 days, Klonopin 0.5 mg 1x/day. Selegiline 5-10mg once every week, and possibly Mocolobemide 75 mg 2x/day (or another WEAK serotonergic, to add 5ht3 agonism, counteracting Memantine's 5ht3 antagonism). And maybe Nicotine, just for added benefit (and to counteract Memantine's Nicotinic ACHr antagonism.)


If possible by any means, I would try to obtain Ketamine, Agomelatine, Tandospirone/Flesinoxan, a Serotonin Releaser of some kind, Buprenorphine, Codeine, Amisulpride, Dimebolin, any 5ht2c antagonist, and a COMT inhibitor.

[rocknroll714]

Originally Posted by Vini Vidi Vici

i despise all SSRIs and SNRIs. I thought MAOIs would be different , because they work for so many people. One could almost say that an MAOI would work for anyone, if they could tolerate the side effects...however, I personally hate Parnate. I feel no emotion, no drive to do anything, and i can't enjoy anything. I can say in complete truth that i felt better taking Tramadol + Xanax. On Parnate, my anxiety/worry is greatly reduced. However, i just don't care. I have no motivation to talk to anyone. So even in the presence of people, i still suffer considerably, because i cannot think of anything to say, because i feel nothing. I have no emotions anymore, just as i had no emotions on SSRIs.... SA is reduced. but there is no point...either way, i don't talk to anyone. at least i used to care

You just described my experience with Nardil to a tee.

[crayzyMed]

Originally Posted by Vini Vidi Vici

sorry about my rambling last post...i doubt it was relevant to the topic. most people actually do Great on MAOIs.

but soon, i hope to change my medication regimen to the following:

Dextroamphetamine 10mg 3x/day, Tramadol 50mg 3x/day(or other Opiate), Memantine 5-20mg once every 2-4 days, Klonopin 0.5 mg 1x/day. Selegiline 5-10mg once every week, and possibly Mocolobemide 75 mg 2x/day (or another WEAK serotonergic, to add 5ht3 agonism, counteracting Memantine's 5ht3 antagonism). And maybe Nicotine, just for added benefit (and to counteract Memantine's Nicotinic ACHr antagonism.)


If possible by any means, I would try to obtain Ketamine, Agomelatine, Tandospirone/Flesinoxan, a Serotonin Releaser of some kind, Buprenorphine, Codeine, Amisulpride, Dimebolin, any 5ht2c antagonist, and a COMT inhibitor.

Why would you take both DXM and memantine? Just take memantine on its own every day. And why do you want to counteract the 5HT3 antagonism? Taking moclobemide for this is a bad idea. Moclobemide wont have much effect as its a weak drug and would only increase your chances of getting serotonin syndrome(when combining with DXM for example).

Also why counteract memantine nicotinic antagonism?

[JayDontCareEh]

Originally Posted by crayzyMed

My list of things i consider usefull for social anxiety (not by personal experiences, but by many succesfull anecdotal reports).

- Stimulants (like dexedrine or adderall)

Can you be prescribed Dexedrine without having to see a Psychologist?

[crayzyMed]

Originally Posted by JayDontCareEh

Can you be prescribed Dexedrine without having to see a Psychologist?

It depends on your country, in my country (belguim) its possible.

[Vini Vidi Vici]

Originally Posted by rocknroll714

You just described my experience with Nardil to a tee.

LOL, it kinda just popped into my thought processes today...that was exactly what you had described with Nardil, and i totally understand now. I was in a state of denial after you reported such a negative experience with Nardil....i didn't want to believe you. I wanted Parnate to be AWESOMe....but i see the truth now..i see the light. You were completely right.

[Vini Vidi Vici]

Originally Posted by crayzyMed

Why would you take both DXM and memantine? Just take memantine on its own every day. And why do you want to counteract the 5HT3 antagonism? Taking moclobemide for this is a bad idea. Moclobemide wont have much effect as its a weak drug and would only increase your chances of getting serotonin syndrome(when combining with DXM for example).

Also why counteract memantine nicotinic antagonism?

DXM?....oh not Dextromethorphan, the stuff in Cough Syrup. I was referring to Dextroamphetamine, the D-isomer of Amphetamine (which is more active and less anxiogenic than L-methamphetamine). However, i guess they both could use the same abbreviation.

I must admit that i have virtually NO knowledge whatsoever as to the mechanism of 5ht3 receptors....however, i know some people with OCD have reported improvements with 5ht3 antagonists. Nevertheless, 5ht3 antagonism presumably would reduce the dopamine release caused by D-amphetamine and Tramadol...i would rather have the Dopamine release. Also, In some of the reports ive seen, it appears people experience "flat, anhedonic, disgusting" feelings on Memantine. Possibly, could these feelings be attributed to more than just the NMDA antagonism? What if some of this was caused by 5ht3 antagonism and Nicotinic Acetylcholine antagonism? And here is my most uneducated assumption-- I like the effects of Nicotine. It reduces my OCD, and releases Dopamine. So woudln't nAChR antagonism be a negative/bad thing? I assumed i would have to use nicotine to bring my nAChr activity back to baseline activity.....

[crayzyMed]

I was reading your post too fast, tought you mentioned DXM.

Memantine has never been reported to reduce the effects of amphetamine, this does seem to be the case with ondansetron, probably because its more potent as an 5HT3 antagonist, memantine wont do any harm because of that property.

Also, In some of the reports ive seen, it appears people experience "flat, anhedonic, disgusting" feelings on Memantine.

Tolerance builds to these effects.

Memantine blocks the effects of nicotine, but with the cocktail your planning i wouldnt see any need to use nicotine.

[Vini Vidi Vici]

Originally Posted by crayzyMed

I was reading your post too fast, tought you mentioned DXM.

Memantine has never been reported to reduce the effects of amphetamine, this does seem to be the case with ondansetron, probably because its more potent as an 5HT3 antagonist, memantine wont do any harm because of that property.


Tolerance builds to these effects.

Memantine blocks the effects of nicotine, but with the cocktail your planning i wouldnt see any need to use nicotine.

cool...im glad to know that it doesnt block 5ht3 receptors super strongly thats not cool.

i think alot of the reason i like nicotine is cuz ive been addicted to it in the past. i used to smoke a pack a day sometimes, along with chewing alot of nicotine gum....i always think about it. even though ive been officialy off it for over 3 months, i still always think about it. i cant stop thinking about the cigarette, inhaling the smoke, blowing it out, and feeling awesome for a little while. anything that attempts to block nicotine from working scares me....