SSRI>normal>MAO-I (advice?)

[Indifferent]

Does anyone have a clue of what could be wrong with my brain chemistry based on the following:

In my "standard state" I suffer(ed) from social anxiety(though it has gotten a lot better in recent times), anhedonia, lack of sexual drive, loss of concentration, lack of motivation, "obsessively" delving in past negative experiences, depression, irritability, feeling tired etc.

Cipralex (Essitalopram) made me feel somewhat better, it eased the social anxiety, made me more social, helped with irritability and kept the thoughts of past negative or shameful experiences out of my head. But it didn't help with the other problems.

Then I switched to Aurorix (Moclobemid). Now I haven't used it for very long yet, but I think that it has actually made me feel worse than standard. Thoughts of past negative or shameful experiences again force their way into my thoughts and my irritability is back worse than ever. And I don't think that it does anything positive, well maybe it helps with the social anxiety.

Now I'm not quite sure of what type of medication to try next...

[crayzyMed]

Moclobemide is considered to be very weak, nothing like the "real" maoi's.

[Vini Vidi Vici]

Originally Posted by Indifferent

Does anyone have a clue of what could be wrong with my brain chemistry based on the following:

In my "standard state" I suffer(ed) from social anxiety(though it has gotten a lot better in recent times), anhedonia, lack of sexual drive, loss of concentration, lack of motivation, "obsessively" delving in past negative experiences, depression, irritability, feeling tired etc.

Cipralex (Essitalopram) made me feel somewhat better, it eased the social anxiety, made me more social, helped with irritability and kept the thoughts of past negative or shameful experiences out of my head. But it didn't help with the other problems.

Then I switched to Aurorix (Moclobemid). Now I haven't used it for very long yet, but I think that it has actually made me feel worse than standard. Thoughts of past negative or shameful experiences again force their way into my thoughts and my irritability is back worse than ever. And I don't think that it does anything positive, well maybe it helps with the social anxiety.

Now I'm not quite sure of what type of medication to try next...

youd have to take a high dose of mocolobemide for it to be effective....its serotonergic action is likely not as strong as that of cipralex's. so it would make sense that some of the shameful and negative thoughts are coming back. thats exaclty what i experienced when i stopped taking SSRIs. You would probably benefit from raising both dopamine and serotonin, so possibly moclobemide would help in high doses, 2 times or so a day..

[gordonjohnson008]

For most antidepressants, it takes awhile for them to kick in. It's best to decide whether or not they are helping after approximately 1 month (well really it varies depending on the medication, talk to your doctor).

[jim_morrison]

Originally Posted by Vini Vidi Vici

youd have to take a high dose of mocolobemide for it to be effective....its serotonergic action is likely not as strong as that of cipralex's. so it would make sense that some of the shameful and negative thoughts are coming back. thats exaclty what i experienced when i stopped taking SSRIs. You would probably benefit from raising both dopamine and serotonin, so possibly moclobemide would help in high doses, 2 times or so a day..

I agree, and since you mention anhedonia, loss of concentration, lack of motivation, depression, irritability, feeling tired etc which sounds like atypical depression, you may do better on something like prozac rather than aurorix, prozac would push serotonin harder like cipralex did, but also push dopamine and noradrenaline a bit more than cipralex, to help with the atypical depression. SNRIs are also another option.

[euphoria]

Moclobemide helped my depression somewhat, but I don't remember it doing much for anxiety. It made me more agitated than calm. To be honest, I don't think it is a very good med. Maybe would be good if you had lethargic depression, and used a high dose.

[rocknroll714]

Moclobemide is a joke of a drug.

[Vini Vidi Vici]

i agree. i don't know why i even suggested taking a higher dose of it....i mean sometimes when i post i look at it later and im like why did i write this.... but i guess if you take a lot of a joke of a drug, maybe it might cause some minor improvement.
moclobemide it gave me horrible nausea and made me really anxious. but then i took Agomelatine and Tianeptine to counter the side effects, and i ended up being ok. i still think its weird how Nardil and Parnate cause virtually no nausea, well Parnate caused none in me..

[Vini Vidi Vici]

Originally Posted by rocknroll714

Moclobemide is a joke of a drug.

i have a question - how similiar would you Compare Mianserin to Mirtazapine? do you think it would result in any positive effects when Mianserin is combined with Parnate in a low dose? if mianserin blocks all those bad serotonin receptors, would it result in an increase of dopamine, or do you think id end up at simply baseline, due to the 5ht2a and 5ht3 antagonism? i can't think of any better 5ht2c antagonist that accesible that i can get. Agomelatine costs about 4.00$ per pill...and it lasts for 3 hours. lame.

[jim_morrison]

I agree that it's a joke of a drug, and for the side effects it causes, and lack of efficacy it has, it's drug interactions don't justify it's use.

[jim_morrison]

Originally Posted by Vini Vidi Vici

i have a question - how similiar would you Compare Mianserin to Mirtazapine? do you think it would result in any positive effects when Mianserin is combined with Parnate in a low dose? if mianserin blocks all those bad serotonin receptors, would it result in an increase of dopamine, or do you think id end up at simply baseline, due to the 5ht2a and 5ht3 antagonism? i can't think of any better 5ht2c antagonist that accesible that i can get. Agomelatine costs about 4.00$ per pill...and it lasts for 3 hours. lame.

I've taken both and I found that mianserin has alot more side effects, while efficacy is about the same. So if your main objective is to save money then if I were you I'd just get a script for mirtazapine from your doc.

[Vini Vidi Vici]

Originally Posted by jim_morrison

I've taken both and I found that mianserin has alot more side effects, while efficacy is about the same. So if your main objective is to save money then if I were you I'd just get a script for mirtazapine from your doc.

sweet. thanks man, that was all i needed to hear. i just wanted to know how mianserin actually compared to mirtaz by someone who had taken them both. so since i don't like mirtaz, i probably wouldn't like mianserin. i don't think im gonna bother. but was mianserin more sedating?

[jim_morrison]

Yeah for me it seemed more sedating, thanks to the alpha 1 blockade i guess, the postural hypotension is somewhat anoying thanks to that too.