03-15-2013, 08:08 PM
Join Date: May 2011
I'm only theorizing here, but since serotonin is on a seesaw like mechanism with dopamine (for the most part) then something like an SSRI would be notorious at blunting the dopaminergic action of a stimulant.
Since Effexor has a greater affinity for serotonin than say, Cymbalta, I hypothesis that Cymbalta (with a more balanced ratio of Sert to NA reuptake would allow amphetamines to work better.
From what i understand, Effexor is strongest on Sert followed by NA and then at higher dosages DA.
So therefore, trying an SNRI that has a better ratio of Sert to NA may allow DA to work better...
However, i could see Effexor at the 300+ mark being more synergistic with amphetamine, due to the induction of its effects on DA. But, im guessing this would put quite a strain on the cardiovascular system and BP monitoring would be recommended.
Dx: Bipolar I, ADD Inattentive
- GAD + Panic attacks
- Migraine Headaches
Zyprexa Zydis 5mg
Zopiclone 7.5-15mg prn
Clonazepam 2mg prn (once a week)
Valium 10mg prn (once a week)
Previous useless meds: Dosulepin 50mg, Lithium 900mg Lexapro 20mg, Lyrica 100mg, Moclobemide 450mg, Prozac 60mg, Saphris 10mg Sodium Valproate 1500mg, Sumatriptan 50mg, Temazepam 20mg, Topamax 100-150mg,